Official EU label nameGlossary entry 307

4,5-DIAMINO-1-((4-CHLOROPHENYL)METHYL)-1H-PYRAZOLE-SULFATE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 8 of 13 indexed market datasets: 8 country records and 0 EU Annex records. Every result and evidence gap is listed below.

8 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:163183-00-4

Ingredient index records:

4,5-DIAMINO-1-((4-CHLOROPHENYL)METHYL)-1H-PYRAZOLE-SULFATE

Cosmetic functions: HAIR DYEING

1H-Pyrazole-4,5-diamine,1-[(4-chlorophenyl)methyl]-, sulfate (2:1)

Inventory restriction note: II/1218

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8 matched or reported names

4,5-DIAMINO-1-((4-CHLOROPHENYL)METHYL)-1H-PYRAZOLE-SULFATE4,5-Diamino-1-((4-Chlorophenyl)Methyl)-1H-Pyrazole Sulfate, when used as a substance in hair dye products4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate,4,5-二氨基-1-（（4-氯苯基）甲基）-1H －吡唑硫酸盐 — 4,5-Diamino-1-（（4-Chlorophenyl）Methyl）-1H-Pyrazole Sulfate （CAS No. 163183-00-4）황산 4,5-디아미노-1-((4-클로르페닐)메칠)-1H-피라졸4,5-diamino-1-((4-clorofenil)metil)-1H-pi razol, quando usado como substância que entra na composição de corantes capilares4,5-Diamino-1-((4-Chlorophenyl)Methyl)-1H-Pyrazole Sulfate, when used as a substance in hair dye products (CAS No. 163183-00-4)

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

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Market	Result	Records	Dataset	Meaning / next action
European Union EU	No local match	0	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain GB	Prohibited	1Open record 1	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	Review every linked record and exact conditions.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Prohibited	1Open record 1	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	Prohibited	1Open record 1	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Review every linked record and exact conditions.
China CN	Prohibited	1Open record 1	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	Review every linked record and exact conditions.
Japan JP	No local match	0	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	Prohibited	1Open record 1	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Review every linked record and exact conditions.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	Prohibited	1Open record 1	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	Review every linked record and exact conditions.
India IN	Prohibited	1Open record 1	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	Review every linked record and exact conditions.
Saudi Arabia SA	Prohibited	1Open record 1	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	Review every linked record and exact conditions.

Matching market records and conditions

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026

4,5-Diamino-1-((4-Chlorophenyl)Methyl)-1H-Pyrazole Sulfate, when used as a substance in hair dye productsProhibited

GB Cosmetics Regulation, Annex II, entry 1218 · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye productsProhibited

Schedule 4, reference 1218, source row 1258 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate,Prohibited

ASEAN Annex II, reference 1218 · 2026-1

China

NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

4,5-二氨基-1-（（4-氯苯基）甲基）-1H －吡唑硫酸盐 — 4,5-Diamino-1-（（4-Chlorophenyl）Methyl）-1H-Pyrazole Sulfate （CAS No. 163183-00-4）Prohibited

Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 191 · NMPA Announcement No. 74 of 2021, effective 2021-05-26

South Korea

MFDS Notice 2026-19, effective 18 March 2026

황산 4,5-디아미노-1-((4-클로르페닐)메칠)-1H-피라졸Prohibited

화장품 안전기준 등에 관한 규정, 별표 1, record 1-1277 · 2026-19

Brazil

ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

4,5-diamino-1-((4-clorofenil)metil)-1H-pi razol, quando usado como substância que entra na composição de corantes capilaresProhibited

4,5-diamino-1-((4-clorofenil)metil)-1H-pi razol, quando usado como substância que entra na composição de corantes capilares

RDC 529/2021 consolidated annex, entry 1218 (through RDC 1.030/2026) · RDC 529/2021 consolidated through RDC 1.030/2026

India

Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

4,5-Diamino-1-((4-Chlorophenyl)Methyl)-1H-Pyrazole Sulfate, when used as a substance in hair dye products (CAS No. 163183-00-4)Prohibited

Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

IS 4707 (Part 2):2025 Annex A, entry 1191 · IS 4707 (Part 2):2025, fifth revision

Saudi Arabia

SFDA live prohibited/restricted lists, snapshot 30 August 2026

4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye productsProhibited

SFDA prohibited list, page 122, row 4 · live-snapshot-2026-08-30

Chemical identity and properties

PubChem 2D chemical structure for CAS 163183-00-4

CAS 163183-00-4PubChem CID 71587557

4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole-sulfate

IUPAC name: bis(1-[(4-chlorophenyl)methyl]pyrazole-4,5-diamine);sulfuric acid

Molecular formula: C20H24Cl2N8O4S
Molecular weight: 543.4 g/mol
Exact mass: 542.1018278 Da
Topological polar surface area: 223.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 10
Covalent units: 3
Defined stereocentres: 0

Also known as

UNII-777Z83LTZ8777Z83LTZ81H-Pyrazole-4,5-diamine, 1-((4-chlorophenyl)methyl)-, sulfate (2:1)4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole-sulfate [INCI]1H-Pyrazole-4,5-diamine, 1-[(4-chlorophenyl)methyl]-, sulfate (2:1)RefChem:1984921-(4-Dhlorobenzyl)-1H-pyrazole-4,5-diamine hemisulfate4,5-Diamino-1-((4-Chlorophenyl)Methyl)- 1H-Pyrazole-Sulfate

2 more reported names

Sulfuric acid--1-[(4-chlorophenyl)methyl]-1H-pyrazole-4,5-diamine (1/2)1H-aPyrazole-a4,a5-adiamine, 1-a[(4-achlorophenyl)amethyl]a-a, sulfate (2:1)

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External database identifiers

EPA DTXSID:DTXSID90892456

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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