STYRENE
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 6 of 13 indexed market datasets: 5 country records and 1 EU Annex records. Every result and evidence gap is listed below.
A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.
Resolved substance identity
Ethenyl-benzene; Vinylbenzene; Phenylethylene; Styrol; Styrolene; Cinnamene
Inventory restriction note: II/1575
3 matched or reported names
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | Prohibited | 1Open record 1 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | Review every linked record and exact conditions. |
| Great Britain GB | Prohibited | 1Open record 1 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | Review every linked record and exact conditions. |
| Canada CA | No local match | 0 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | The Hotlist is an administrative compliance tool, not an exhaustive safety approval list. |
| New Zealand NZ | Prohibited | 1Open record 1 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | Review every linked record and exact conditions. |
| ASEAN ASEAN | Prohibited | 1Open record 1 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Review every linked record and exact conditions. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | No local match | 0 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Korean source wording is canonical and other positive lists/notices may still apply to the formulation. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | No local match | 0 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026. |
| India IN | Prohibited | 1Open record 1 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | Review every linked record and exact conditions. |
| Saudi Arabia SA | Prohibited | 1Open record 1 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | Review every linked record and exact conditions. |
Matching market records and conditions
Great Britain
GB retained Regulation 1223/2009 schedules, effective 15 August 2026New Zealand
Cosmetic Products Group Standard schedules effective 1 January 2026ASEAN
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026India
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)Saudi Arabia
SFDA live prohibited/restricted lists, snapshot 30 August 2026Exact Annex II–VI evidence
Styrene
Chemical identity and properties
Styrene
Styrene is a vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species. It has a role as a mutagen, a mouse metabolite and a plant metabolite. It is a volatile organic compound, a member of styrenes and a vinylarene. — ChEBI
- IUPAC name
- styrene
- Molecular formula
- C8H8
- Molecular weight
- 104.15 g/mol
- Exact mass
- 104.062600255 Da
- XLogP3
- 2.9
- Topological polar surface area
- 0.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 0
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:27452
- ChEMBL:CHEMBL285235
- EPA DTXSID:DTXSID2021284
- PubMed:38070821
- PubMed:36912746
- PubMed:36416909
- PubMed:34668566
- PubMed:34324853
- PubMed:33064461
- PubMed:28962520
- PubMed:28951217
- PubMed:28678435
- PubMed:26505805
- PubMed:26463279
- PubMed:26343807
Evidence from additional scientific databases
EMBL-EBI ChEBI
styrene
A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.
- Formula
- C8H8
- Average mass
- 104.152 g/mol
- Monoisotopic mass
- 104.06260 Da
- Formal charge
- 0
- styrenes — is a (CHEBI:26799)
- vinylarene — is a (CHEBI:51324)
- volatile organic compound — is a (CHEBI:134179)
- mutagen — has role (CHEBI:25435)
- plant metabolite — has role (CHEBI:76924)
- mouse metabolite — has role (CHEBI:75771)
- mutagen — has role (CHEBI:25435)
- plant metabolite — has role (CHEBI:76924)
- mouse metabolite — has role (CHEBI:75771)
- styrenes — is a (CHEBI:26799)
- vinylarene — is a (CHEBI:51324)
- volatile organic compound — is a (CHEBI:134179)
Additional curated names
Cross-references from this source
- CAS: 100-42-5 — NIST Chemistry WebBook
- CAS: 100-42-5 — KEGG COMPOUND
- CAS: 100-42-5 — ChemIDplus
- REGISTRY_NUMBER: 1071236 — Reaxys
- REGISTRY_NUMBER: 2991 — Gmelin
- MANUAL_X_REF: c0115 — UM-BBD
- MANUAL_X_REF: C07083 — KEGG COMPOUND
- MANUAL_X_REF: C07083 — KEGG COMPOUND
- MANUAL_X_REF: CPD-1092 — MetaCyc
- MANUAL_X_REF: HMDB0034240 — HMDB
- MANUAL_X_REF: Styrene — Wikipedia
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2021-03-05. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 914 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 914 °F (490 °C) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 490 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 293 to 295 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 145.3 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 145.00 to 146.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 145 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 293 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 145 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 293 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Colorless to yellowish, oily liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Viscous liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.906 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.9016 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Percent in saturated air at 760 mm Hg & 15 °C: 0.57; density of saturated vapor-air mixture at 760 mm Hg & 15 °C: 1.02 (Air = 1) Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.91 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.91 Source: Occupational Safety and Health Administration (OSHA)
- Density: 0.9016 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.91 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 88 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: The Guide from the Emergency Response Guidebook is for "Styrene monomer, stabilized." 34 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 32.0 °C (89.6 °F) - closed cup Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 88 °F (31 °C) - closed cup Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 34.4 °C (Tag closed cup); 36.7 °C (Tag open cup). Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 31 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 88 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 88 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: log Kow = 2.95 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 2.95 Source: Human Metabolome Database (HMDB)
- LogP: 3.0 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -24 to -23 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -30.65 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: Latent heat of fusion: 10.95 kJ/mole (at melting point); Latent heat of sublimation: 43.9 kJ/mole (25 °C); Heat of formation: 103.8 kJ/mole (25 °C); Ionization potential: 8.42 eV Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -33 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -30.6 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -23 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -30.65 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -23 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Characteristic, sweet, balsamic, almost floral odor that is extremely penetrating Source: Hazardous Substances Data Bank (HSDB)
- Odor: Aromatic odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Sweet, floral odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: If pure, sweet and pleasant, but usually contains aldehydes that have a typical penetrating smell, sharp, sweet, and unpleasant. Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Styrene monomer, stabilized appears as a clear colorless to dark liquid with an aromatic odor. Vapors heavier than air and irritating to the eyes and mucous membranes. Subject to polymerization. If the polymerization takes place inside a closed container, the container may rupture violently. Less dense than water and insoluble in water. Used to make plastics, paints, and synthetic rubber. Source: CAMEO Chemicals
- Physical Description: Liquid; Large Crystals; Liquid; Wet Solid; Gas Vapor; Wet Solid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless to yellow, oily liquid with a sweet, floral odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS-TO-YELLOW OILY LIQUID. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colorless to yellow, oily liquid with a sweet, floral odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless to yellow, oily liquid with a sweet, floral odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: Index of refraction: 1.5440 at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: less than 1 mg/mL at 66 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: In water, 300 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Insoluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in ethanol, ether, and acetone; miscible with benzene; slightly soluble in carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in carbon disulfide, alcohol, ether, methanol, acetone Source: Hazardous Substances Data Bank (HSDB)
- Solubility: For more Solubility (Complete) data for Styrene (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 0.31 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml at 20 °C: 0.03 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: 0.03% Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 4.3 mmHg at 59 °F ; 9.5 mmHg at 86 °F; 10 mmHg at 95 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 6.4 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 6.40 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.67 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 5 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 7.5 [mm Hg] @28.6 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 5 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 0.696 cP at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Styrene Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 2A: Probably carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 60: (1994) Some Industrial Chemicals; Volume 82: (2002) Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene; Volume 121: (2019) Styrene, Styrene-7,8-oxide, and Quinoline Source: International Agency for Research on Cancer (IARC)
- Publication Year: 2019 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 2018 Source: International Agency for Research on Cancer (IARC)
- Substance: Styrene Source: NTP Technical Reports
- NTP Technical Report: TR-185: Bioassay of Styrene for Possible Carcinogenicity (CASRN 100-42-5) (1979 ) Source: NTP Technical Reports
- Peer Review Date: 10/25/78 Source: NTP Technical Reports
- Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: Equivocal Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- Exposure Routes: Oral (L1832) ; Inhalation (L1832) ; Dermal (L1832) Source: Toxin and Toxin Target Database (T3DB)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- ERG2024, Guide 128P (Styrene monomer, stabilized): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush - If this chemical contacts the skin, flush the contaminated skin with water. Where there is evidence of skin irritation, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (3 of 6114) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H304 (50.6%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (98%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (52%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H361 (35.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H372 (73.8%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H412 (49%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P321, P331, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 6114 reports by companies from 92 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 3 of 6114 reports by companies.; There are 91 notifications provided by 6111 of 6114 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Health Effects: Styrene causes nervous system depression and may be carcinogenic. Animals studies have also shown that hearing loss and liver damage may occur. (L1831, L1832) Source: Toxin and Toxin Target Database (T3DB)
- NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Specific Notice: W - No water: Materials that react violently or explosively with water. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Cancer, Neurological (Nervous System) Source: Agency for Toxic Substances and Disease Registry (ATSDR)
- Target Organs: Hematologic; Hepatic; Nervous Source: EPA Integrated Risk Information System (IRIS)
- Target Organs: Eyes, skin, respiratory system, central nervous system, liver, reproductive system Source: The National Institute for Occupational Safety and Health (NIOSH)
- Toxicity Summary: IDENTIFICATION AND USE: Styrene is a colorless to yellowish, oily liquid. It is used in the manufacture of plastics, synthetic rubber, and resins, and as an insulator. It is also used as a flavoring agent for ice cream and candy. HUMAN STUDIES: Humans acutely exposed to styrene by inhalation to 800 ppm (3.4 mg/L) for 3 hr experience immediate eye and throat irritation, increased nasal mucous secretion, metallic taste, drowsiness, and vertigo. After test termination, slight muscular weakness, accompanied by inertia and depression were noted. Long-term contact with styrene results in blistering of the skin and development of dermatitis, which is thought to result from defatting of the skin. Effects on the liver (e.g., increased serum bile acid and enhanced activity of plasma enzymes) and reproductive system (e.g., decreased frequency of births and increased frequency of spontaneous abortions in female workers) have been reported. Epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumors. No adequate human studies are available for styren Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: Styrene 7,8-oxide, a metabolite of styrene, can form DNA adducts by binding to deoxyguanosine. It is also mutagenic and causes increased frequency of sister chromatid exchange, chromosomal aberrations, micronucleated cells, and DNA strand breaks. (L1831) Source: Toxin and Toxin Target Database (T3DB)
- Environmental Bioconcentration: BCF ranges of 15-140 and 12-113 were measured in fish for styrene using carp (Cyprinus carpio) which were exposed over an 8-week period to 0.3 and 0.03 mg/L, respectively(1). A BCF of 13.5 was measured in goldfish for styrene(2). According to a classification scheme(3), these measured BCF values suggest the potential for bioconcentration in aquatic organisms is low to high(SRC). Calculated biomagnification factors (BMF) for styrene in water respiring organisms (zooplankton, forage and predatory fish) and air breathing organisms (reptile, amphibian, sea bird, marine mammal, terrestrial herbivore and carnivore, human) were all less than 1(4). [ Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an experimental Koc value of 912(2), indicates that styrene is expected to have low mobility in soil(SRC). Volatilization of styrene from moist soil surfaces may be an important fate process(SRC) given a Henry's Law constant of 2.75X10-3 atm-cu m/mole(3). Styrene is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 6.4 mm Hg at 25 °C(4). In an experimental study using loamy soil, 26% of applied styrene (2 mg/kg) volatilized after 31 days(5); volatilization of styrene from soil surfaces is expected to be slower than in water(6). A 100% of theoretical BOD after 2 weeks using activated sludge in the Japanese MITI test(7) suggests that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an experimental Koc value of 912(2), indicates that styrene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 2.75X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3 hours and 4 days, respectively(SRC). According to a classification scheme(5), measured BCF ranges from 12-140 in carp(6), suggests the potential for bioconcentration in aquatic organisms is high to low(SRC). A 100% of theoretical BOD after 2 weeks using activated sludge in the Japanese MITI test(7) suggests that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), styrene, which has a vapor pressure of 6.4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase styrene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.6 hours(SRC), calculated from its rate constant of 5.8X10-11 cu cm/molecule-sec at 25 °C(3). Vapor-phase styrene is also degraded in the atmosphere by reaction with ozone and nitrate radicals; the half-lives for these reactions in air are 24 and 3.7 hours, respectively(4). Styrene does not strongly absorb light at wavelengths above 270 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight since sunlight consists of wavelengths above 290 nm(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Antioxidant; Fuel agents; Monomers; Binder; Solvent; Adhesion/cohesion promoter; Intermediate; Filler; Not Known or Reasonably Ascertainable; Viscosity modifiers Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Plasticizer; Filler; Not Known or Reasonably Ascertainable; Intermediate; Etching agent; Solvent; Other; Monomers; Antioxidant; Fuel agents Source: EPA Chemical Data Reporting (CDR)
- Uses: Styrene is used predominately in the production of polystyrene plastics and resins. Styrene is also used as an intermediate in the synthesis of materials used for ion exchange resins and to produce copolymers. Source: EPA Hazardous Air Pollutants
- Sources/Uses: Styrene is used extensively in the manufacture of plastics, rubber, and resins. About 90,000 workers, including those who make boats, tubs and showers, are potentially exposed to styrene. [http://www.osha-slc.gov/SLTC/styrene/] Used to make polystyrene for packaging, insulation for buildings and refrigeration equipment, and disposable cups and containers; Also used in styrene-butadiene rubber, other polymers, and resins to make boats, shower stalls, tires, automotive parts, etc.; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Plastic Composites Manufacturing [Category: Industry]; Burning Synthetic Polymers [Category: Burn] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Activities with risk of exposure: Sculpturing plastics [Category: Hobbies]; Smoking cigarettes [Category: Food & Drugs] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Manufacture of plastics; synthetic rubber; resins; insulator. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Polystyrene; SBR /styrene-butadiene-rubber/, ABS /acrylonitrile-butadiene-styrene/ and SAN /styrene-acrylonitrile/ resins; protective coatings (styrene-butadiene latex; alkyds); styrenated polyesters; rubber-modified polystyrene; copolymer resins; intermediate. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Reported uses (ppm):; Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association) [Table#625] Source: Hazardous Substances Data Bank (HSDB)
- Uses: The major uses for styrene are in plastics, latex paints and coatings, synthetic rubbers, polyesters and styrene-alkyd coatings. The broad spectrum of uses of these products includes construction, packaging, automotive and household goods. Packaging is the single largest application for styrenecontaining resins, particularly foams, used as fillers and cushioning. Construction applications include pipes, fittings, tanks, lighting fixtures and corrosion-resistant products. Household goods include synthetic marble, flooring, disposable tableware and moulded furnishings. Transport applications range from tyres to reinforced plastics and automobile body putty. Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for Styrene (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Styrene is used to make plastics and rubber. It is a precursor to polystyrene and may be found in insulation, fiberglass, plastic pipes, automobile parts, shoes, drinking cups and other food containers, and carpet backing. Low levels of styrene also occur naturally in a variety of foods such as fruits, vegetables, nuts, beverages, and meats. Small amounts of styrene can be transferred to food from styrene-based packaging material. (L1831) Source: Toxin and Toxin Target Database (T3DB)
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|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
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