Official EU label nameGlossary entry 2780
AZELAIC ACID
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 4 of 13 indexed market datasets: 4 country records and 0 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
4
Evidence gaps
9
Resolved identifiers
6
A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.
Resolved substance identity
CAS:123-99-952457-54-2132499-85-517265-13-327825-99-6
EC:204-669-1
Ingredient index records:
5 matched or reported names
AZELAIC ACIDAzelaic acid and its saltsAzelaic acid1,7-헵탄디카르복실산(아젤라산), 그염류 및 유도체Azelaic Acid
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | No local match | 0 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review. |
| Great Britain GB | No local match | 0 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework. |
| Canada CA | Restricted | 1Open record 1 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | Review every linked record and exact conditions. |
| New Zealand NZ | No local match | 0 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative. |
| ASEAN ASEAN | Prohibited | 1Open record 1 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Review every linked record and exact conditions. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | Prohibited | 1Open record 1 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Review every linked record and exact conditions. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | No local match | 0 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026. |
| India IN | No local match | 0 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | The standards are separate controlled publications; absence from a locally indexed excerpt is not permission. |
| Saudi Arabia SA | Restricted | 1Open record 1 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | Review every linked record and exact conditions. |
No market rows match this filter.
Matching market records and conditions
ASEAN
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026South Korea
MFDS Notice 2026-19, effective 18 March 2026Saudi Arabia
SFDA live prohibited/restricted lists, snapshot 30 August 2026Chemical identity and properties
CAS 123-99-9PubChem CID 2266
Azelaic Acid
Nonanedioic acid is an alpha,-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups. It has a role as an antibacterial agent, an antineoplastic agent, a dermatologic drug and a plant metabolite. It is a dicarboxylic fatty acid and an alpha,omega-dicarboxylic acid. It is a conjugate acid of an azelaate and an azelaate(2-). — ChEBI
- IUPAC name
- nonanedioic acid
- Molecular formula
- C9H16O4
- Molecular weight
- 188.22 g/mol
- Exact mass
- 188.10485899 Da
- XLogP3
- 1.6
- Topological polar surface area
- 74.6 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
FinaceaAnchoic acidLepargylic acid1,7-Heptanedicarboxylic acidAzelexSkinorenHeptanedicarboxylic acidEmerox 1110
16 more reported names
1,9-Nonanedioic acidEmerox 1144n-Nonanedioic acidAcido azelaicoacide azelaiqueacidum azelaicumAzelaic acid, technical grade1,7-DicarboxyheptaneZK 62498ZK-62498Finacea FoamF2VW3D43YTNSC-19493CHEBI:481314-02-00-02055 (Beilstein Handbook Reference)hydron;nonanedioate
External database identifiers
- ChEBI:CHEBI:48131
- ChEMBL:CHEMBL1238
- EPA DTXSID:DTXSID8021640
- PubMed:22920095
- PubMed:22849351
- PubMed:22822212
- PubMed:22779176
- PubMed:22777226
- PubMed:22772611
- PubMed:22747347
- PubMed:22693913
- PubMed:22675394
- PubMed:22675387
- PubMed:22675033
- PubMed:22645576
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match2266
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 286.5 °C at 1.00E+02 mm Hg Source: DrugBank
- Boiling Point: 357.1 °C; 287 °C at 100 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: BP: 365 °C (decomposes) Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: Distills above 360 °C with partial anhydride formation. BP: 286.5 °C at 100 mm Hg; 265 °C at 50 mm Hg; 237 °C at 15 mm Hg; 225 dg C at 10 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Monoclinic prismatic needles Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellowish to white crystalline powder Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Leaflets or needles Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.225 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- pKa: 4.55 (at 25 °C) Source: DrugBank
- Dissociation Constants: pKa = 4.55 Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 210 °C (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.57 Source: DrugBank
- LogP: log Kow = 1.57 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.57 Source: Human Metabolome Database (HMDB)
- Melting Point: 106.5 °C Source: DrugBank
- Melting Point: 160.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 106.5 °C Source: Human Metabolome Database (HMDB)
- Physical Description: Dry Powder; Other Solid; Large Crystals Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Yellowish to white solid; [HSDB] White flakes; [Acros Organics MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Refractive Index: Index of refraction = 1.4303 at 111 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 2400 mg/L (at 20 °C) Source: DrugBank
- Solubility: Slightly soluble in ethy ether, benzene, DMSO; soluble in ethanol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in hot water, alcohol and organic solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: One liter of water dissolves 1.0 g at 1.0 °C; 2.4 g at 20 °C; 8.2 g at 50 °C; 22 g at 50 °C ... 1000 g ether dissolves 18.8 g at 11 °C and 26.8 g at 15 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 2.40X10+3 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 2.4 mg/mL Source: Human Metabolome Database (HMDB)
- Vapor Pressure: 0.00000001 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 1.07X10-8 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
- Exposure Routes: Approximately 4% of the topically applied azelaic acid is systemically absorbed. Source: Toxin and Toxin Target Database (T3DB)
- Note: This chemical does not meet GHS hazard criteria for 6.5% (71 of 1087) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (40.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (93.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1087 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 71 of 1087 reports by companies.; There are 11 notifications provided by 1016 of 1087 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Toxicity Summary: The exact mechanism of action of azelaic acid is not known. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes. In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases. In anaerobic bacteria, azelaic acid impedes glycolysis. Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation. Azelaic acid may be effective against both inflamed and noninflamed lesions. Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules. Source: Toxin and Toxin Target Database (T3DB)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 1,7-heptanecarboxylic acid(SRC), using a log Kow of 1.57(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a log Kow of 1.57(2) and a regression-derived equation(3), indicates that 1,7-heptanecarboxylic acid is expected to have moderate mobility in soil(SRC). The pKa of 1,7-heptanecarboxylic acid is 4.55(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization from moist soil is not expected because the acid exists as an anion and anions do not volatilize. 1,7-Heptanecarboxylic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.07X10-8 mm Hg(6). Biodegradation data were not available(SRC, 2008) but straight chain carboxylic acids are expected to readily biodergade(7). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a log Kow of 1.57(2) and a regression-derived equation(3), indicates that 1,7-heptanecarboxylic acid is expected to adsorb to suspended solids and sediment(SRC). A pKa of 4.55(4) indicates 1,7-heptanecarboxylic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2008) but straight chain carboxylic acids are expected to readily biodergade(8). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,7-heptanecarboxylic acid, which has a vapor pressure of 1.07X10-8 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 1,7-heptanecarboxylic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 40 hrs(SRC), calculated from its rate constant of 9.8X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 1,7-heptanecarboxylic acid may be removed from the air by wet or dry deposition(SRC). 1,7-Heptanecarboxylic acid does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Monomers; Lubricating agent; Wetting agent (non-aqueous); Binder; Intermediate; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Plasticizer Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Azelaic Acid Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Found in rancid oleic acid; [Merck Index] Used in organic syntheses, lacquers, alkyd resins, low-temperature plasticizers, adhesives, polyamides, urethane elastomers, and for the treatment of acne; [HSDB] Natural component of foods such as whole grain cereals and animal products; [REPROTOX] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Azelaic acid is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses. Azelaic acid is also used in treating of acne. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Organic synthesis, lacquers, product of hydrotropic salts, alkyd resins, polyamides, polyester adhesives, low-temperature plasticizers, urethane elastomers Source: Hazardous Substances Data Bank (HSDB)
- Uses: Use (kg; approx.) in Germany (2009): >1000; Consumption (g per capita; approx.) in Germany (2009): 0.0122; Calculated removal (%): 92.2 Source: NORMAN Suspect List Exchange
- Uses: For the topical treatment of mild-to-moderate inflammatory acne vulgaris. Source: Toxin and Toxin Target Database (T3DB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 132499-85-5PubChem CID 159815
Azelaic acid, disodium salt
- IUPAC name
- disodium;nonanedioate
- Molecular formula
- C9H14Na2O4
- Molecular weight
- 232.18 g/mol
- Exact mass
- 232.06874749 Da
- Topological polar surface area
- 80.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
RefChem:135012Disodium azelateNonanedioic acid, disodium saltdisodium nonanedioateNonanedioic acid, sodium salt (1:2)0P4H8NH3UJUNII-0P4H8NH3UJsodium azelate
3 more reported names
EINECS 241-298-4SODIUM AZELATE (2:1)DB-254558
External database identifiers
- EPA DTXSID:DTXSID40889659
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 17265-13-3PubChem CID 159815
Azelaic acid, disodium salt
- IUPAC name
- disodium;nonanedioate
- Molecular formula
- C9H14Na2O4
- Molecular weight
- 232.18 g/mol
- Exact mass
- 232.06874749 Da
- Topological polar surface area
- 80.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
RefChem:135012Disodium azelateNonanedioic acid, disodium saltdisodium nonanedioateNonanedioic acid, sodium salt (1:2)0P4H8NH3UJUNII-0P4H8NH3UJsodium azelate
3 more reported names
EINECS 241-298-4SODIUM AZELATE (2:1)DB-254558
External database identifiers
- EPA DTXSID:DTXSID40889659
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 52457-54-2PubChem CID 162680
Azelaic acid, dipotassium salt
- IUPAC name
- dipotassium;nonanedioate
- Molecular formula
- C9H14K2O4
- Molecular weight
- 264.40 g/mol
- Exact mass
- 264.01662189 Da
- Topological polar surface area
- 80.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
RefChem:589030Dipotassium azelateAzelaic acid, potassium saltDipotassium nonanedioateNonanedioic acid, dipotassium saltNonanedioic acid, potassium salt (1:2)Nonanedioic acid, potassium saltPotassium nonanedioate
5 more reported names
Potassium azelateEINECS 257-931-2UNII-C98170693JEINECS 243-190-2RTMGQVSGXYZVTE-UHFFFAOYSA-L
External database identifiers
- EPA DTXSID:DTXSID501014948
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Additional authoritative substance research
These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identityFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identityILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identityJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identityNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identityOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identityUS EPA CompTox CTX APIs
DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identityContinue the compliance check
1. Confirm identity
Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.
2. Review restrictions
Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.
3. Verify the formula
Evaluate concentration, product type, purity, warnings, claims and each target market before making a compliance decision.
Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision