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Official EU label nameGlossary entry 27399

SPERMIDINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
1

Resolved substance identity

CAS:124-20-9
Ingredient index records:
SPERMIDINE
Cosmetic functions: ANTIOXIDANT, HAIR CONDITIONING

1,4-Butanediamine, N1-(3-aminopropyl)-

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1 matched or reported name
SPERMIDINE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name SPERMIDINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

Check the markets and their sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 124-20-9
CAS 124-20-9PubChem CID 1102

Spermidine

Spermidine is a triamine that is the 1,5,10-triaza derivative of decane. It has a role as an autophagy inducer, a geroprotector and a fundamental metabolite. It is a triamine and a polyazaalkane. It is a conjugate base of a spermidine(3+). — ChEBI

IUPAC name
N'-(3-aminopropyl)butane-1,4-diamine
Molecular formula
C7H19N3
Molecular weight
145.25 g/mol
Exact mass
145.157897619 Da
XLogP3
-1.0
Topological polar surface area
64.1 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

1,5,10-Triazadecane4-Azaoctamethylenediamine4-Azaoctane-1,8-diamineSpermidinN-(3-aminopropyl)butane-1,4-diamine1,8-Diamino-4-azaoctaneN-(3-Aminopropyl)-1,4-butanediamine1,4-Butanediamine, N-(3-aminopropyl)-
16 more reported names
1,4-Butanediamine, N1-(3-aminopropyl)-(4-aminobutyl)(3-aminopropyl)amineN-(3-Aminopropyl)-1,4-butane-diamine1,4-Diaminobutane, N-(3-aminopropyl)-N-(4-Aminobutyl)-1,3-diaminopropaneU87FK77H25CHEBI:16610RefChem:184613204-689-0N1-(3-Aminopropyl)butane-1,4-diamineN-(3-Aminopropyl)-1,4-diaminobutaneBRN 1698591N1-(3-Aminopropyl)-1,4-butanediamineAI3-26636N-(3-Aminopropyl)-4-aminobutylamineSPD
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External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match1102

Attributed physical-property, hazard, environmental and use annotations.

  • Boiling Point: 129 °C at 1.40E+01 mm Hg Source: DrugBank
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (81.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 83 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Health Effects: Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Uremic toxins such as spermidine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869). Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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