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Official EU label nameGlossary entry 24294

rh-POLYPEPTIDE-2

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
1

Resolved substance identity

CAS:52500-60-4
Ingredient index records:
RH-POLYPEPTIDE-2
Cosmetic functions: SKIN CONDITIONING

rh-Polypeptide-2 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Thioredoxin. It contains a maximum of 105 amino acids which may contain disulfide bonds and/or glycosylation. The protein consi…

Inventory restriction note: II/416

1 matched or reported name
RH-POLYPEPTIDE-2

Official name structure and source evidence

This section separates facts supplied by external records from structure derived only from the exact official label wording.

Structured interpretation of the official EU INCI label

Matchedlabel-analysis-v1 · EU 2025/1175

The official label identifies a peptide- or protein-related cosmetic material.

Identity type inferred from wording
peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Open evidence source

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name rh-POLYPEPTIDE-2.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

Chemical identity and properties

PubChem 2D chemical structure for CAS 52500-60-4
CAS 52500-60-4PubChem CID 3037043

Thioredoxins

Thioredoxin is a small dithiol protein and specific reductant for major allergenic proteins present in foods from animal and plant products. It is a 12-kD oxidoreductase enzyme encoded by TXN and TXN2 genes that contains a dithiol-disulfide active site. It plays an essential role as an antioxidant in neutralizing food allergens and redox signalling. Allergens containing disulfide bonds are inactivated when reduced by thioredoxin. — DrugBank

IUPAC name
[(1S)-1-carboxy-2-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)ethyl]-trimethylazanium
Molecular formula
C9H16N3O2S+
Molecular weight
230.31 g/mol
Exact mass
230.09632294 Da
XLogP3
-0.3
Topological polar surface area
93.5 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
1

Also known as

THIOREDOXINTHIOREDOXIN HUMANReduced thioredoxinRefChem:933000CG-GF4BIO-FD&C THIOREDOXINRecombinant ATL Derived FactorCHEBI:15033
7 more reported names
CLAPIEL DETOC PACK SUPER LIFTING PACK((1S)-1-carboxy-2-(2-sulfanyl-1H-imidazol-4-yl)ethyl)trimethylazaniumtrimethyl-[(2S)-1-oxidanyl-1-oxidanylidene-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)propan-2-yl]azaniumThioredoxin from Escherichia coliSR-05000001462SR-05000001462-1BRD-K26341917-001-01-3
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision