Official EU label nameGlossary entry 23758

PYROGLUTAMYL DIPEPTIDE-30 AMIDE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence

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Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:24305-27-9

Ingredient index records:

PYROGLUTAMYL DIPEPTIDE-30 AMIDE

Cosmetic functions: SKIN CONDITIONING

L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-,Throtropin Releasing Factor,TRF,TRH

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1 matched or reported name

PYROGLUTAMYL DIPEPTIDE-30 AMIDE

Official name structure and source evidence

This section separates facts supplied by external records from structure derived only from the exact official label wording.

Structured interpretation of the official EU INCI label

Matchedlabel-analysis-v1 · EU 2025/1175

The official label identifies a peptide- or protein-related cosmetic material.

Identity type inferred from wording: peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

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Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name PYROGLUTAMYL DIPEPTIDE-30 AMIDE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 24305-27-9

CAS 24305-27-9PubChem CID 638678

Protirelin

Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide. — ChEBI

IUPAC name: (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Molecular formula: C16H22N6O4
Molecular weight: 362.38 g/mol
Exact mass: 362.17025320 Da
XLogP3: -2.5
Topological polar surface area: 150.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 3

Also known as

ThyroliberinLopremoneSynthetic TRHRifathyroinThypinoneThyrotropin-releasing factorTSH-releasing factorProtireline

16 more reported names

Thyrotropic-releasing factor5-Oxo-L-prolyl-L-histidyl-L-prolinamideABBOTT-38579ProtirelinumTHYREL TRHSynthetic tsh-releasing factorRelefact TRHAbbott 38579Protirelin, syntheticProtirelina5-oxo-pro-his-pro-nh2L-Pyroglutamyl-L-histidyl-L-prolineamideProtireline [INN-French]Protirelinum [INN-Latin]FDA 1725L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-

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External database identifiers

ChEBI:CHEBI:35940
ChEMBL:CHEMBL1472
EPA DTXSID:DTXSID0023533
PubMed:37600512
PubMed:37244566
PubMed:35948163
PubMed:34536669
PubMed:31838899
PubMed:28739588
PubMed:22661809
PubMed:21808723
PubMed:19332331
PubMed:19036363
PubMed:18689289
PubMed:16889105

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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