Propyl Acetate
- IUPAC name
- propyl acetate
- Molecular formula
- C5H10O2
- Molecular weight
- 102.13 g/mol
- Exact mass
- 102.068079557 Da
- XLogP3
- 1.2
- Topological polar surface area
- 26.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:40116
- ChEMBL:CHEMBL44857
- EPA DTXSID:DTXSID6021901
- PubMed:22924429
- PubMed:21857978
- PubMed:21818287
- PubMed:21754071
- PubMed:21580948
- PubMed:21535646
- PubMed:21042539
- PubMed:20938768
- PubMed:20655446
- PubMed:20599854
- PubMed:19919120
- PubMed:19468317
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 842 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 842 °F (450 °C). Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 455 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 214.9 °F at 760 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 101.5 °C Source: DrugBank
- Boiling Point: 101.3 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 101.00 to 102.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 101.6 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 102 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 215 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 101.5 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 215 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.886 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.8820 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Bulk density: 7.36 lb/gal Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.9 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.880-0.886 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.84 Source: Occupational Safety and Health Administration (OSHA)
- Density: 0.836 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.84 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 58 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: 14 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 55 °F (13 °C) (Closed cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 10 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 55 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 55 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: 1.24 Source: DrugBank
- LogP: log Kow = 1.24 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.24 Source: Human Metabolome Database (HMDB)
- LogP: 1.24 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -139 °F (USCG, 1999) Source: CAMEO Chemicals
- Melting Point: -93 °C Source: DrugBank
- Melting Point: -93 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -93 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -92 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -134 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -134 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Pleasant odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Odor of pears Source: Hazardous Substances Data Bank (HSDB)
- Odor: Mild, fruity odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: N-propyl acetate appears as a clear colorless liquid with a pleasant odor. Flash point 58 °F. Less dense than water, Vapors are heavier than air. Source: CAMEO Chemicals
- Physical Description: CBI; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid with a mild, fruity odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: colourless mobile liquid with a fruity, pear-raspberry odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Physical Description: Colorless liquid with a mild, fruity odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless liquid with a mild, fruity odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: Index of refraction: 1.3844 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.382-1.387 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 2 % (NIOSH, 2024) Source: CAMEO Chemicals
- Solubility: 18900 mg/L (at 20 °C) Source: DrugBank
- Solubility: Miscible with alcohols, ketones, esters, hydrocarbons Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
- Solubility: MISCIBLE WITH CASTOR AND LINSEED OILS Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 1.89X10+4 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 18.9 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml at 16 °C: 1.6 (poor) Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: miscible with alcohol, ether; soluble 1ml in 60ml water Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 1 ml in 1 ml 95% alcohol (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 2% Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 67.21 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Vapor Pressure: 35.9 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: VP: 1 Pa at -69 °C; 10 Pa at -51 °C; 100 Pa at -29 °C; 1kPa at 0 °C; 10 kPa at 40.9 °C; 100 kPa at 101.2 °C (extrapolated) Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 35.9 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 3.3 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 25 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 35.9 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 25 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 0.768 mPa s at 0 °C; 0.544 mPa s at 25 °C; 0.406 mPa s at 50 °C; 0.316 mPa s at 75 °C; 0.255 mPa s at 100 °C Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: Excerpt from NIOSH Pocket Guide for n-Propyl acetate:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: WATER FLUSH PROMPTLY - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 129 (n-Propyl acetate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for 0.4% (11 of 3068) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (99.2%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H319 (99.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336 (99.6%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 3068 reports by companies from 42 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 11 of 3068 reports by companies.; There are 41 notifications provided by 3057 of 3068 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P273, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Eyes, skin, respiratory system, central nervous system Source: The National Institute for Occupational Safety and Health (NIOSH)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for n-propyl acetate(SRC), using a log Kow of 1.24(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that n-propyl acetate is expected to have very high mobility in soil(SRC). Volatilization of n-propyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 2.18X10-4 atm-cu m/mole(3). n-Propyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 35.9 mm Hg at 25 °C(4). A 81.0% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that n-propyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 2.18X10-4(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 7 hours and 5.2 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 1.24(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). n-Propyl acetate gave a 5- and 10-day theoretical BOD of 62% and 80%, respectively, using a settled domestic wastewater seed(8). When the same inoculum was added to sea water, n-propyl acetate 5- and 10-day theoretical BOD was 50% and 70%(8), indicating biodegradation in water is important(SRC). Hydrolysis is expected to occur slowly based on hydrolysis half-lives of about 3 years, 119 days and 12 days at pH 7, 8 and 9, respectively(9). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-propyl acetate, which has a vapor pressure of 35.9 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase n-propyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.7 days(SRC), calculated from its rate constant of 3.4X10-12 cu cm/molecule-sec at 25 °C(3). n-Propyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable; Pigment; Solvent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Solvent; Fuel; Not Known or Reasonably Ascertainable; Intermediate; Pigment Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Propyl Acetate Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used as a solvent, flavoring agent, and chemical intermediate; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Flavoring agents, perfumery, solvent for nitrocellulose and other cellulose derivatives, natural and synthetic resins, lacquers, plastics, organic synthesis, lab reagent Source: Hazardous Substances Data Bank (HSDB)
- Uses: n-Propy acetate ... is a powerful solvent and is used in waxes, and insecticide formulations. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used in alcohol-dilutable inks containing nitrocellulose as a main constituent, polyamide inks, acrylic inks. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Reported uses (ppm):; Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#536] Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.