Official EU label nameGlossary entry 23253

PROLINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:147-85-3609-36-9

EC:205-702-2210-189-3

Ingredient index records:

PROLINE

Cosmetic functions: HAIR CONDITIONING, SKIN CONDITIONING

2-Pyrrolidinecarboxylic acid, (S)-

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2 matched or reported names

PROLINEproline

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name PROLINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 147-85-3

CAS 147-85-3PubChem CID 145742

L-Proline

L-proline is pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles. It has a role as a member of compatible osmolytes, a micronutrient, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and an algal metabolite. It is a L-alpha-amino acid, a glutamine family amino acid, a proline and a proteinogenic amino acid. It is a conjugate base of a L-prolinium. It is a conjugate acid of a L-prolinate. It is an enantiomer of a D-proline. It is a tautomer of a L-proline zwitterion. — ChEBI

IUPAC name: (2S)-pyrrolidine-2-carboxylic acid

Molecular formula: C5H9NO2
Molecular weight: 115.13 g/mol
Exact mass: 115.063328530 Da
XLogP3: -2.5
Topological polar surface area: 49.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

prolineL-(-)-Proline(S)-Pyrrolidine-2-carboxylic acid(-)-Proline2-pyrrolidinecarboxylic acid(-)-(S)-Proline(S)-2-Pyrrolidinecarboxylic acidprolina

16 more reported names

Prolinum(S)-Proline(-)-2-Pyrrolidinecarboxylic acidL-ProlinL-alpha-Pyrrolidinecarboxylic acid(S)-2-CarboxypyrrolidineProlinum [Latin]FEMA No. 33192-Pyrrolidinecarboxylic acid, (S)-PRO (IUPAC abbreviation)CB 1707AI3-26710L-Pro9DLQ4CIU6VNSC 46703L-2-pyrrolidinecarboxylic acid

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External database identifiers

ChEBI:CHEBI:17203
ChEMBL:CHEMBL54922
EPA DTXSID:DTXSID5044021
PubMed:29968805
PubMed:23062336
PubMed:22989233
PubMed:22988852
PubMed:22986818
PubMed:22946499
PubMed:22924394
PubMed:22915995
PubMed:22878559
PubMed:22833679
PubMed:22829593
PubMed:22740038

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 609-36-9

CAS 609-36-9PubChem CID 614

proline dl-form

Proline is an alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. It has a role as a human metabolite and a Daphnia magna metabolite. It is an alpha-amino acid and a member of pyrrolidines. It is a conjugate base of a prolinium. It is a conjugate acid of a prolinate. — ChEBI

IUPAC name: pyrrolidine-2-carboxylic acid

Molecular formula: C5H9NO2
Molecular weight: 115.13 g/mol
Exact mass: 115.063328530 Da
XLogP3: -2.5
Topological polar surface area: 49.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Proline, DL-UNII-DCS9E77JPQDCS9E77JPQCCRIS 8602EINECS 210-189-3NSC 97923NSC-97923PROLINE DL-FORM [MI]

16 more reported names

2-PYRROLIDINYLCARBOXYLIC ACID(+-)-prolineRefChem:202730210-189-3DL-ProlineH-DL-Pro-OHD-Pyrrolidine-2-carboxylic acid2-Pyrrolidine carboxylic acidHproDL-Pyrrolidine-2-carboxylic acidF3157-0002(+/-)-Pyrrolidine-2-carboxylic acidL-Proline homopolymerDL prolineD,L-prolined,1-proline

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External database identifiers

ChEBI:CHEBI:26271
EPA DTXSID:DTXSID9041104
PubMed:23124343
PubMed:23116672
PubMed:23105881
PubMed:23100743
PubMed:23096694
PubMed:23087757
PubMed:23084901
PubMed:23074886
PubMed:23071575
PubMed:23068764
PubMed:23066668
PubMed:23066399

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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