Official EU label nameGlossary entry 20828
P-HYDROXYANISOLE
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 9 of 13 indexed market datasets: 8 country records and 1 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
9
Evidence gaps
4
Resolved identifiers
6
A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.
Resolved substance identity
CAS:150-76-5103-16-2622-62-8
EC:205-769-8203-083-3210-748-1
Ingredient index records:
P-HYDROXYANISOLE
Cosmetic functions: ANTIOXIDANT, REDUCING
4-Methoxyphenol
Inventory restriction note: III/95
10 matched or reported names
P-HYDROXYANISOLEmequinolHydroquinone methylether / Mequinolp-Hydroxyanisolp -HydroxyanisoleHydroquinone methylether (mequinol; p-hydroxyanisol)Hydroquinone methylether / Mequinol p-Hydroxyanisole CAS No 150-76-54-메톡시페놀(히드로퀴논모노메칠에텔또는 p-히드록시아니솔)4 – Benziloxifenol, 4 - metoxifenol e 4 – etoxifeno; 4-etoxifenol (4-ETHOXYPHENOL)Hydroquinone methyleth- er/Mequinol p-hydroxyan- isol (CAS No. 150-76-5)
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | Restricted | 1Open record 1 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | Review every linked record and exact conditions. |
| Great Britain GB | Restricted | 1Open record 1 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | Review every linked record and exact conditions. |
| Canada CA | Restricted | 1Open record 1 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | Review every linked record and exact conditions. |
| New Zealand NZ | Restricted | 1Open record 1 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | Review every linked record and exact conditions. |
| ASEAN ASEAN | Restricted | 1Open record 1 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Review every linked record and exact conditions. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | Prohibited | 1Open record 1 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Review every linked record and exact conditions. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | Prohibited | 1Open record 1 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | Review every linked record and exact conditions. |
| India IN | Restricted | 1Open record 1 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | Review every linked record and exact conditions. |
| Saudi Arabia SA | Restricted | 1Open record 1 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | Review every linked record and exact conditions. |
No market rows match this filter.
Matching market records and conditions
Great Britain
GB retained Regulation 1223/2009 schedules, effective 15 August 2026Canada
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025New Zealand
Cosmetic Products Group Standard schedules effective 1 January 2026ASEAN
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026South Korea
MFDS Notice 2026-19, effective 18 March 2026Brazil
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026India
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)Saudi Arabia
SFDA live prohibited/restricted lists, snapshot 30 August 2026Exact Annex II–VI evidence
Annex IIIentry 95
Open full regulatory recordP-HYDROXYANISOLE
Product scope: Artificial nail systems
Maximum concentration: 0.02% (after mixing for use)
Restrictions: Professional use
Warnings: For professional use only Avoid skin contact Read directions for use carefully
Chemical identity and properties
CAS 103-16-2PubChem CID 7638
Monobenzone
Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a dermatologic drug, an allergen and a melanin synthesis inhibitor. It is functionally related to a hydroquinone. — ChEBI
- IUPAC name
- 4-phenylmethoxyphenol
- Molecular formula
- C13H12O2
- Molecular weight
- 200.23 g/mol
- Exact mass
- 200.083729621 Da
- XLogP3
- 3.4
- Topological polar surface area
- 29.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
4-(Benzyloxy)phenolHydroquinone monobenzyl etherBenoquinP-(BENZYLOXY)PHENOLBenzoquinDepigmanLeucodinineMonobenzon
16 more reported names
Monobenzyl hydroquinoneSuperlitePigmexAgerite alba4-(Phenylmethoxy)phenol4-(Benzyloxyl)phenolHydroquinone benzyl etherDermochinonaCarmifalp-Hydroxyphenyl benzyl etherAlba-DomePhenol, 4-(phenylmethoxy)-Benzyl p-hydroxyphenyl etherMonobenzyl ether hydroquinoneMonobenzonaMonobenzonum
External database identifiers
- ChEBI:CHEBI:34380
- ChEMBL:CHEMBL1388
- EPA DTXSID:DTXSID2020717
- PubMed:35435491
- PubMed:25455453
- PubMed:23013281
- PubMed:22566895
- PubMed:21911918
- PubMed:21754122
- PubMed:21716544
- PubMed:21689385
- PubMed:21599003
- PubMed:21566576
- PubMed:21429753
- PubMed:21326294
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:34380
monobenzone
The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.
- Formula
- C13H12O2
- Average mass
- 200.237 g/mol
- Monoisotopic mass
- 200.08373 Da
- Formal charge
- 0
- benzyl ether — is a (CHEBI:59859)
- dermatologic drug — has role (CHEBI:50177)
- allergen — has role (CHEBI:50904)
- melanin synthesis inhibitor — has role (CHEBI:64933)
- hydroquinone — has functional parent (CHEBI:17594)
- dermatologic drug — has role (CHEBI:50177)
- allergen — has role (CHEBI:50904)
- melanin synthesis inhibitor — has role (CHEBI:64933)
- benzyl ether — is a (CHEBI:59859)
Additional curated names
4-(benzyloxy)phenol4-(Benzyloxyl)phenol4-Benzyloxy-phenol4-Benzyloxyphenol4-(Phenylmethoxy)phenolBenzyl p-hydroxyphenyl etherHydroquinone benzyl etherHydroquinone monobenzyl etherMONOBENZYL ETHER OF HYDROQUINONEMonobenzyl hydroquinoneNSC-2132p-(Benzyloxy)phenolp-Hydroxyphenyl benzyl ether
Cross-references from this source
- CAS: 103-16-2 — ChemIDplus
- CAS: 103-16-2 — KEGG COMPOUND
- MANUAL_X_REF: 1834 — DrugCentral
- MANUAL_X_REF: C14244 — KEGG COMPOUND
- MANUAL_X_REF: D05072 — KEGG DRUG
- MANUAL_X_REF: DB00600 — DrugBank
- MANUAL_X_REF: EP0175701 — Patent
- MANUAL_X_REF: LSM-5642 — LINCS
- MANUAL_X_REF: Monobenzone — Wikipedia
- MANUAL_X_REF: WO8504101 — Patent
- REGISTRY_NUMBER: 1958305 — Reaxys
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-09-29. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7638
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: LUSTROUS LEAFLETS FROM WATER Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: WHITE CRYSTALLINE POWDER Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.26 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 3.2 Source: DrugBank
- LogP: 3.2 Source: Human Metabolome Database (HMDB)
- Melting Point: 122 °C Source: DrugBank
- Melting Point: 122.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 110 - 118 °C Source: Human Metabolome Database (HMDB)
- Odor: ODORLESS Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Tan solid; Insoluble in water; [Hawley] White powder; [Alfa Aesar MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Solubility: 251 mg/L Source: DrugBank
- Solubility: SOLUBILITY IN BOILNG WATER ABOUT 1.0 G/100 ML; SOL IN ALC, ETHER, BENZENE Source: Hazardous Substances Data Bank (HSDB)
- Solubility: INSOL IN WATER Source: Hazardous Substances Data Bank (HSDB)
- Solubility: FREELY SOL IN ACETONE Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Practically insoluble in petroleum hydrocarbons, very soluble in benzene and alkalies. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3.92e-02 g/L Source: Human Metabolome Database (HMDB)
- Vapor Pressure: 0.0000225 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 80 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified Source: NITE-CMC
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Sources/Uses: Used as a solvent and in perfumes, soap, plastics, and pharmaceuticals; [Hawley] Used as an antioxidant (rubber, paraffins, and polyvinyl chloride), stabilizer, polymerization inhibitor, intermediate, and depigmentor to treat hyperpigmentation of the skin; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: ANTIOXIDANT FOR PARAFFINS AND POLYVINYL CHLORIDE, POLYPROPYLENE AND POLYPROPYLENE OXIDE; CHEM INT IN ORGANIC SYNTHESIS Source: Hazardous Substances Data Bank (HSDB)
- Uses: Rubber antioxidant, stabilizer, polymerization inhibitor, chemical intermediate. Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION (VET) Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 150-76-5PubChem CID 9015
4-Methoxyphenol
- IUPAC name
- 4-methoxyphenol
- Molecular formula
- C7H8O2
- Molecular weight
- 124.14 g/mol
- Exact mass
- 124.052429494 Da
- XLogP3
- 1.3
- Topological polar surface area
- 29.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Mequinol4-Hydroxyanisolep-Hydroxyanisolep-MethoxyphenolPhenol, 4-methoxy-HYDROQUINONE MONOMETHYL ETHERMEHQLeucobasal
16 more reported names
Leucodine BP-GuaiacolMechinolumNovo-DermoquinonaHydroquinone methyl etherHQMMEp-Hydroxymethoxybenzene1-Hydroxy-4-methoxybenzenepara-methoxyphenolMonomethyl ether hydroquinonePMF (antioxidant)USAF AN-7Mono methyl ether hydroquinoneMechinoloMequinolumBMS 181158
External database identifiers
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 622-62-8PubChem CID 12150
4-Ethoxyphenol
4-Ethoxyphenol is a member of phenols and an aromatic ether. — ChEBI
- IUPAC name
- 4-ethoxyphenol
- Molecular formula
- C8H10O2
- Molecular weight
- 138.16 g/mol
- Exact mass
- 138.068079557 Da
- XLogP3
- 1.8
- Topological polar surface area
- 29.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Phenol, 4-ethoxy-P-ETHOXYPHENOLHydroquinone monoethyl etherp-Hydroxyphenetole4-EthyloxyphenolPhenol, p-ethoxy-4-ethoxy-phenol1-Ethoxy-4-hydroxybenzene
16 more reported names
Ethoxyphenol, p-NSC 9885FEMA No. 3695Ether monoethylique de l'hydroquinonep-ethoxy-phenolEINECS 210-748-1BRN 1907114UNII-605352N8AQNSC-9885Ether monoethylique de l'hydroquinone [French]HYDROQUINONE MONO ETHYL ETHERHYDROQUINONE MONOETHYL ETHER [FHFI]FEMA 36954-06-00-05719 (Beilstein Handbook Reference)RefChem:98845210-748-1
External database identifiers
- ChEBI:CHEBI:179262
- ChEMBL:CHEMBL225153
- EPA DTXSID:DTXSID3044251
- PubMed:21618624
- PubMed:21210681
- PubMed:18728835
- PubMed:12738276
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Additional authoritative substance research
These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identityFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identityILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identityJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identityNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identityOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identityUS EPA CompTox CTX APIs
DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identityContinue the compliance check
1. Confirm identity
Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.
2. Review restrictions
Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.
3. Verify the formula
Evaluate concentration, product type, purity, warnings, claims and each target market before making a compliance decision.
Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision