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EU cosmetic ingredients, restrictions and safety
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Official EU label nameGlossary entry 17493

NOBILETIN

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
1

Resolved substance identity

CAS:478-01-3
Ingredient index records:
NOBILETIN
Cosmetic functions: ANTIMICROBIAL, ANTIOXIDANT, PRESERVATIVE

2-(3,4-Dimethoxyphenyl)-5,6,7,8- tetramethoxy-4H-1-benzopyran-4-one,4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy,3',4',5,6,7,8-hexamethoxyflavone

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1 matched or reported name
NOBILETIN

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name NOBILETIN.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 478-01-3
CAS 478-01-3PubChem CID 72344

Nobiletin

Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. It has a role as an antineoplastic agent and a plant metabolite. It is functionally related to a flavone. — ChEBI

IUPAC name
2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
Molecular formula
C21H22O8
Molecular weight
402.4 g/mol
Exact mass
402.13146766 Da
XLogP3
3.0
Topological polar surface area
81.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
8
Covalent units
1
Defined stereocentres
0

Also known as

5,6,7,8,3',4'-Hexamethoxyflavone2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-oneD65ILJ7WLYNSC-767514H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-NSC-618903CHEBI:7602RefChem:43297
16 more reported names
Hexamethoxyflavone3',4',5,6,7,8-Hexamethoxyflavone2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-oneSpectrum3_000921SPBio_001654HMS2234A09Flavone, 5,6,7,8,3',4'-hexamethoxy2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one3,4,5,6,7,8-HexamethoxyflavoneCCRIS 9012UNII-D65ILJ7WLYNSC 76751nobiretinnobliletinhexamethoxy fl avoneNobiletin (Standard)
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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