Official EU label nameGlossary entry 13325

HYDROXYPROLINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:51-35-4

EC:200-091-9

Ingredient index records:

HYDROXYPROLINE

Cosmetic functions: ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING

L-4-hydroxyproline

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1 matched or reported name

HYDROXYPROLINE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name HYDROXYPROLINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 51-35-4

CAS 51-35-4PubChem CID 5810

L-Hydroxyproline

Trans-4-hydroxy-L-proline is an optically active form of 4-hydroxyproline having L-trans-configuration. It has a role as a mouse metabolite, a plant metabolite and a human metabolite. It is a tautomer of a trans-4-hydroxy-L-proline zwitterion. — ChEBI

IUPAC name: (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid

Molecular formula: C5H9NO3
Molecular weight: 131.13 g/mol
Exact mass: 131.058243149 Da
XLogP3: -3.3
Topological polar surface area: 69.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 2

Also known as

trans-4-Hydroxy-L-prolinehydroxyprolineHyprohydroxy-L-proline(4R)-4-hydroxy-L-prolinetrans-L-HydroxyprolineL-Proline, 4-hydroxy-, (4R)-trans-Hydroxyproline

16 more reported names

4-Hydroxy-2-pyrrolidinecarboxylic aciddelta-HydroxyprolineL-Proline, 4-hydroxy-, trans-(2S,4R)-4-hydroxyprolineRMB44WO89XLUMISTORL-threo-4-hydroxyprolineNSC-46704(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acidCHEBI:18095[2S,4R]-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACIDCHEBI:18240oxyproline(2S,4R)-4-hydroxypyrrolidin-1-ium-2-carboxylateNMH-Procis 4 Hydroxyproline

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External database identifiers

ChEBI:CHEBI:18095
ChEMBL:CHEMBL352418
EPA DTXSID:DTXSID10883225
PubMed:29968805
PubMed:22998630
PubMed:22764742
PubMed:22168216
PubMed:22167201
PubMed:22148719
PubMed:21951102
PubMed:21501141
PubMed:21482820
PubMed:21247092
PubMed:21219648
PubMed:21210682

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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