Official EU label nameGlossary entry 13286

HYDROXYISOLEUCINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:55399-93-4

Ingredient index records:

HYDROXYISOLEUCINE

Cosmetic functions: HUMECTANT, SKIN CONDITIONING

(4S)-4-Hydroxy-L-Isoleucine

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1 matched or reported name

HYDROXYISOLEUCINE

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name HYDROXYISOLEUCINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 55399-93-4

CAS 55399-93-4PubChem CID 6918732

Hydroxyisoleucine

(4S)-4-hydroxy-L-isoleucine is an L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent. It has a role as a plant metabolite. It is an amino alcohol, a non-proteinogenic L-alpha-amino acid and a L-isoleucine derivative. It is a tautomer of a (4S)-4-hydroxy-L-isoleucine zwitterion. — ChEBI

IUPAC name: (2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid

Molecular formula: C6H13NO3
Molecular weight: 147.17 g/mol
Exact mass: 147.08954328 Da
XLogP3: -2.8
Topological polar surface area: 83.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 3

Also known as

(4S)-4-Hydroxy-L-isoleucineUNII-4SWT01T54O(4S)-4-hydroxyisoleucine4SWT01T54OL-Ribonic acid, 2-amino-2,3,5-trideoxy-3-methyl-CHEBI:790794-HYDROXYISOLEUCINE, (+)-2-amino-2,3,5-trideoxy-3-methyl-L-ribonic acid

16 more reported names

4-HYDROXYISOLEUCINE (USP-RS)4-HYDROXYISOLEUCINE [USP-RS]RefChem:390694-HYDROXYISOLEUCINE (CONSTITUENT OF FENUGREEK SEED)(2S,3R,4S)-4-HYDROXYISOLEUCINEID-1101(2S,3R,4S)-2-Amino-4-hydroxy-3-methyl-pentanoic acidrel-(2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acidAdyvia(4S)-4-Hydroxy-L-isoleucine, from fenugreek seed, >=98.0% (TLC)4-HYDROXY-L-ISOLEUCINE(2S,3R,4S)-4-hydroxy-L-isoleucine4-OH-IleH-Ile(4-OH)-OH(4S)-Hydroxy-L-isoleucine(4S)-4-Hydroxy-L-isoleucine;

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External database identifiers

ChEBI:CHEBI:79079
ChEMBL:CHEMBL508094
EPA DTXSID:DTXSID90203947
PubMed:22869132
PubMed:22397995
PubMed:21069315
PubMed:20665018
PubMed:20307090
PubMed:19850012
PubMed:18621529

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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