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EU cosmetic ingredients, restrictions and safety
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Official EU label nameGlossary entry 11857

HEXAMIDINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 4 of 13 indexed market datasets: 4 country records and 0 EU Annex records. Every result and evidence gap is listed below.

4 markets with evidence
Markets checked
13
Markets with evidence
4
Evidence gaps
9
Resolved identifiers
5

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:3811-75-4659-40-593841-83-9
EC:211-533-5299-055-3
Ingredient index records:
HEXAMIDINE
Cosmetic functions: PRESERVATIVE

Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-

Inventory restriction note: V/47

Open full local profile
5 matched or reported names
HEXAMIDINEHexamidine, Hexamidine diisethionate, Hexamidine paraben1,6-Di(4-amidinophenoxy)-N-hexane (hexamidine) and its salts (including isethionate and p‑hydroxybenzoate)1,6-Di(4-amidinophenoxy)-n-hexane (Hexamidine) and its salts (including isethionate and p-hydroxybenzoate (+) Hexamidine (CAS No. 3811-75-4), Hexamidine diisethionate (CAS No. 659-40-5), Hexamidine paraben(CAS No. 93841-83-9),헥사미딘(1,6-디(4-아미디노페녹시)-n-헥산) 및 그 염류(이세치오네이트 및 p-하이드록시벤조에이트)

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Swipe or scroll horizontally to see dataset coverage and next actions.

MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
Permitted list with conditions1Open record 1
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
Review every linked record and exact conditions.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
Permitted list with conditions1Open record 1
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
Review every linked record and exact conditions.
ASEAN
ASEAN
Permitted list with conditions1Open record 1
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Review every linked record and exact conditions.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
Restricted1Open record 1
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Review every linked record and exact conditions.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Matching market records and conditions

Chemical identity and properties

PubChem 2D chemical structure for CAS 3811-75-4
CAS 3811-75-4PubChem CID 65130

Hexamidine

Hexamidine is a polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol. It has a role as an antimicrobial agent and an antiseptic drug. It is a member of guanidines, an aromatic ether and a polyether. It is functionally related to a hexane-1,6-diol. — ChEBI

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide
Molecular formula
C20H26N4O2
Molecular weight
354.4 g/mol
Exact mass
354.20557608 Da
XLogP3
2.9
Topological polar surface area
118.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

HexamidinaHexamidinum4,4'-(1,6-Hexanediylbis(oxy))bis-benzenecarboximidamide3483C2H13HCHEBI:87184Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-1,6-di(para-amidinophenoxy)hexane4-{[6-(4-carbamimidoylphenoxy)hexyl]oxy}benzene-1-carboximidamide
16 more reported names
4-((6-(4-carbamimidoylphenoxy)hexyl)oxy)benzene-1-carboximidamide1,6-di-(4-amidinophenoxy)hexaneRefChem:786246D08AC04R01AX07R02AA18S01AX08S03AA054,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE4,4'-[hexane-1,6-diylbis(oxy)]di(benzene-1-carboximidamide)Hexamidinum [INN-Latin]Hexamidina [INN-Spanish]Hexamidine [INN:BAN:DCF]UNII-3483C2H13HHEXAMIDINE [MI]Hexamidine (INN/BAN)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 659-40-5
CAS 659-40-5PubChem CID 3080571

Hexamidine Diisethionate

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(2-hydroxyethanesulfonic acid)
Molecular formula
C24H38N4O10S2
Molecular weight
606.7 g/mol
Exact mass
606.20293577 Da
Topological polar surface area
284.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
12
Covalent units
3
Defined stereocentres
0

Also known as

Hexamidine isethionatehexomedinhexamidine isetionate023XA5Z50LNSC-115848RF-2535Laryngomedin NHexomedin N
16 more reported names
RefChem:146090211-533-5DesomedineHexamidine diisetionate4,4'-(Hexane-1,6-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate)HexomedineOphtamedineEsomedina2-HYDROXYETHANESULPHONIC ACID, COMPOUND WITH 4,4'-[HEXANE-1,6-DIYLBIS(OXY)]BIS[BENZENECARBOXAMIDINE] (2:1)2535 RPRP 25354-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (22535 R. P.DesmedineUNII-023XA5Z50L
Open full PubChem recordPubChem annotations3D structure image

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 93841-83-9
CAS 93841-83-9PubChem CID 46235485

p-Hydroxybenzoic acid, compound with p,p'-(hexane-1,6-diylbis(oxy))bis(benzamidine) (2:1)

IUPAC name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(4-hydroxybenzoic acid)
Molecular formula
C34H38N4O8
Molecular weight
630.7 g/mol
Exact mass
630.26896418 Da
Topological polar surface area
233.0 Ų
Hydrogen-bond donors
8
Hydrogen-bond acceptors
10
Covalent units
3
Defined stereocentres
0

Also known as

P-hydroxybenzoic acid, compound with p,p'-[hexane-1,6-diylbis(oxy)]bis(benzamidine) (2:1)RefChem:858083Hexamidine diparabenHEXAMIDINE PARABENUNII-XBD058OZ1MXBD058OZ1MEINECS 299-055-34-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;4-hydroxybenzoic acid
2 more reported names
4,4'-(hexane-1,6-diylbis(oxy))dibenzimidamide bis(4-hydroxybenzoate)BENZENECARBOXIMIDAMIDE, 4,4'-(1,6-HEXANEDIYLBIS(OXY))BIS-, BIS(4-HYDROXYBENZOATE)
Open full PubChem recordPubChem annotations3D structure image

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity

US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity

Continue the compliance check

1. Confirm identity

Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.

2. Review restrictions

Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.

3. Verify the formula

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision