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Official EU label nameGlossary entry 11819

HESPERETIN

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

Resolved substance identity

CAS:520-33-2
EC:208-290-2
Ingredient index records:
HESPERETIN
Cosmetic functions: ANTIOXIDANT, SKIN CONDITIONING

4H-1-Benzopyran-4-one, 2,3-Dihydro-5,7-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-

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1 matched or reported name
HESPERETIN

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name HESPERETIN.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

Check the markets and their sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 520-33-2
CAS 520-33-2PubChem CID 72281

Hesperetin

Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a member of 4'-methoxyflavanones, a monomethoxyflavanone, a trihydroxyflavanone and a member of 3'-hydroxyflavanones. It is a conjugate acid of a hesperetin(1-). — ChEBI

IUPAC name
(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
Molecular formula
C16H14O6
Molecular weight
302.28 g/mol
Exact mass
302.07903816 Da
XLogP3
2.4
Topological polar surface area
96.2 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
1

Also known as

Hesperitin3',5,7-Trihydroxy-4'-methoxyflavanone(-)-hesperetin5,7,3'-Trihydroxy-4'-methoxyflavanone(-)-(S)-hesperetinEriodictyol 4'-monomethyl etherNSC-57654FEMA NO. 4313
16 more reported names
Q9Q3D557F14H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-CHEBI:28230(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-oneFlavanone, 3',5,7-trihydroxy-4'-methoxy-4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-2,3-DIHYDRO-5,7-DIHYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONERefChem:783778208-290-2(S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-oneYSO2Prestwick_908Cyanidanon 4'-methyl ether 1626(S)-HesperetinNSC 57654(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortalUS EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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