Official EU label nameGlossary entry 10255

ETIDRONIC ACID

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 7 of 13 indexed market datasets: 6 country records and 1 EU Annex records. Every result and evidence gap is listed below.

7 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:2809-21-43794-83-014860-53-8

EC:220-552-8

Ingredient index records:

ETIDRONIC ACID

Cosmetic functions: CHELATING

Phosphonic acid, (1-hydroxyethylidene)bis-

Inventory restriction note: III/53

Open full local profile

8 matched or reported names

ETIDRONIC ACIDetidronic acidEtidronic acid(1-Hydroxyethylidene)diphosphonic acid and its saltsEtidronic acid and its salts (1-hydro-xyethylidene-di-phosphonic acid and its salts)(1-Hydroxyethylidene) di-phosphonic acid and its salts Etidronic acid and its salts CAS No 2809-21-4에티드로닉애씨드 및그 염류(1-하이드록시에칠리덴-디-포스포닉애씨드 및 그 염류)(1-Hydroxyethylidene- diphosphonic acid) and its salts Etidronic acid (CAS No. 2809-21-4) 20

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Show rows

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Market	Result	Records	Dataset	Meaning / next action
European Union EU	Restricted	1Open record 1	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	Review every linked record and exact conditions.
Great Britain GB	Restricted	1Open record 1	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	Review every linked record and exact conditions.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Restricted	1Open record 1	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	Restricted	1Open record 1	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Review every linked record and exact conditions.
China CN	No local match	0	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan JP	No local match	0	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	Restricted	1Open record 1	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Review every linked record and exact conditions.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	No local match	0	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India IN	Restricted	1Open record 1	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	Review every linked record and exact conditions.
Saudi Arabia SA	Restricted	1Open record 1	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	Review every linked record and exact conditions.

Matching market records and conditions

European Union

Regulation (EC) 1223/2009 consolidated to 1 May 2026

Etidronic acidAnnex III

(a) Hair product (b) Soap

Maximum concentration: (a) 1.5% (as etidronic acid) (b) 0.2% (as etidronic acid)

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Etidronic acidRestricted

(a) Hair- product · 1,5% (as etidronic acid)

GB Cosmetics Regulation, Annex III, entry 53 · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

Etidronic acid and its salts (1-hydro-xyethylidene-di-phosphonic acid and its salts)Restricted

Product scope: (a) Hair product (b) Soap · Maximum concentration: (a) 1.5% expressed as etidronic acid (b) 0.2% expressed as etidronic acid

Schedule 5, reference 53, source row 75 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

(1-Hydroxyethylidene) di-phosphonic acid and its salts Etidronic acid and its salts CAS No 2809-21-4Restricted

(a) Hair care products (b) Soap · (a) 1.5% expressed as etidronic acid (b) 0.2% expressed as etidronic acid

ASEAN Annex III, reference 53 · 2026-1

South Korea

MFDS Notice 2026-19, effective 18 March 2026

에티드로닉애씨드 및그 염류(1-하이드록시에칠리덴-디-포스포닉애씨드 및 그 염류)Restricted

?두발용 제품류 및 두발염색용 제품류에 산으로서 1.5% ?인체 세정용 제품류에 산으로서 0.2% · 기타 제품에는 사용금지 · 에티드로닉애씨드테트라소듐에티드로네이트테트라포타슘에티드로네이트

화장품 안전기준 등에 관한 규정, 별표 2, record 2-373 · 2026-19

India

Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

(1-Hydroxyethylidene- diphosphonic acid) and its salts Etidronic acid (CAS No. 2809-21-4) 20Restricted

Field of application/use: a)Hair product b)Soap | Maximum authorised concentration: a) 1.5 percent (as etidronic acid) b) 0.2 percent (as etidronic acid)

IS 4707 (Part 2):2025 Annex B, entry 53 · IS 4707 (Part 2):2025, fifth revision

Saudi Arabia

SFDA live prohibited/restricted lists, snapshot 30 August 2026

(1-Hydroxyethylidene)diphosphonic acid and its saltsRestricted

SFDA restricted list, page 7, row 5 · live-snapshot-2026-08-30

Exact Annex II–VI evidence

Annex IIIentry 53

Open full regulatory record

Etidronic acid

Product scope: (a) Hair product (b) Soap

Maximum concentration: (a) 1.5% (as etidronic acid) (b) 0.2% (as etidronic acid)

Chemical identity and properties

PubChem 2D chemical structure for CAS 14860-53-8

CAS 14860-53-8PubChem CID 26938

Tetrapotassium Etidronate

IUPAC name: tetrapotassium;1,1-diphosphonatoethanol

Molecular formula: C2H4K4O7P2
Molecular weight: 358.39 g/mol
Exact mass: 357.7980524 Da
Topological polar surface area: 147.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 7
Covalent units: 5
Defined stereocentres: 0

Also known as

Tetrapotassium (1-hydroxyethylidene)bisphosphonateEINECS 238-928-5CVI36ET72EPhosphonic acid, (1-hydroxyethylidene)bis-, tetrapotassium saltEINECS 267-956-0POTASSIUM ETIDRONATE(1-Hydroxyethylidene)diphosphonic acid, tetrapotassium saltEthane-1-hydroxy-1,1-diphosphonic acid, tetrapotassium salt

16 more reported names

Phosphonic acid, (1-hydroxyethylidene)bis-, potassium saltEC 267-956-01-Hydroxylethanediphosphonic acid, potassium saltHydroxyethylidene diphosphonic acid, potassium saltPhosphonic acid, P,P'-(1-hydroxyethylidene)bis-, potassium salt (1:4)(1-Hydroxyethylidene)bisphosphonic acid, potassium saltPhosphonic acid, (1-hydroxyethylidene) bis-, potassium saltDIPHOSPHONIC ACID, (1-HYDROXYETHYLIDENE)-, TETRAPOTASSIUM SALTPhosphonic acid, P,P'-(1-hydroxyethylidene)bis-, potassium salt (1:?)TETRAPOTASSIUM 1-HYDROXYETHANE-1,1-DIPHOSPHONATE(1-HYDROXYETHYLIDENE) BISPHOSPHONIC ACID, TETRAPOTASSIUM SALTRefChem:897421TETRAPOTASSIUM ETIDRONATE [INCI]267-956-0Potassium (1-hydroxyethane-1,1-diyl)bis(phosphonate)UNII-CVI36ET72E

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID3029732

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 2809-21-4

CAS 2809-21-4PubChem CID 3305

Etidronic Acid

Etidronic acid is a 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces. It has a role as an antineoplastic agent, a chelator and a bone density conservation agent. It is a conjugate acid of an etidronic acid(2-). — ChEBI

IUPAC name: (1-hydroxy-1-phosphonoethyl)phosphonic acid

Molecular formula: C2H8O7P2
Molecular weight: 206.03 g/mol
Exact mass: 205.97452659 Da
XLogP3: -3.7
Topological polar surface area: 135.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 0

Also known as

HEDP1-Hydroxyethylidene-1,1-diphosphonic acidEHDPEtidronsaeureTurpinal SLAcetodiphosphonic acidHydroxyethanediphosphonic acidAcido etidronico

16 more reported names

Acide etidroniqueOxyethylidenediphosphonic acidDequest 2015Dequest Z 010Ferrofos 510Dequest 20101-Hydroxyethane-1,1-diphosphonic acidDiphosphonate (base)1-Hydroxyethanediphosphonic acidPhosphonic acid, (1-hydroxyethylidene)bis-(1-Hydroxyethylidene)diphosphonic acidAcidum etidronicum(Hydroxyethylidene)diphosphonic acid1-Hydroxyethane-1,1-bisphosphonic acidEthane-1-hydroxy-1,1-diphosphonic acid(1-Hydroxyethylidene)bisphosphonic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:4907
ChEMBL:CHEMBL871
EPA DTXSID:DTXSID6023028
PubMed:23022200
PubMed:22988612
PubMed:22966908
PubMed:22951500
PubMed:22797188
PubMed:22733953
PubMed:22717979
PubMed:22678684
PubMed:22675556
PubMed:22654798
PubMed:22639712
PubMed:22629613

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3794-83-0

CAS 3794-83-0PubChem CID 19629

Tetrasodium Etidronate

IUPAC name: tetrasodium;1,1-diphosphonatoethanol

Molecular formula: C2H4Na4O7P2
Molecular weight: 293.96 g/mol
Exact mass: 293.90230359 Da
Topological polar surface area: 147.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 7
Covalent units: 5
Defined stereocentres: 0

Also known as

Tarpinel 4NLTurpinal 4NLSequion 10Na4etidronate tetrasodiumDefloc EN 43Dequest 2016UNII-CZZ9T1T1X4EINECS 223-267-7

16 more reported names

CZZ9T1T1X4Tetrasodium 1-hydroxyethylidene-1,1-diphosphonate(1-Hydroxyethylidene)diphosphonic acid, tetrasodium saltEthane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt1-Hydroxyethylidene-1,1-diphosphonic acid, tetrasodium saltTetrasodium 1-hydroxyethane-1, 1-diphosphonateEC 223-267-7ETIDRONATE TETRASODIUM [WHO-DD](1-Hydroxyethylidene)bisphosphonic acid, tetrasodium saltDIPHOSPHONIC ACID, (1-HYDROXYETHYLIDENE)-, TETRASODIUM SALTRefChem:188886TETRASODIUM ETIDRONATE [INCI]223-267-7(1-Hydroxyethylidene)bis-phosphonic acid tetrasodium saltPhosphonic acid, (1-hydroxyethylidene)bis-, tetrasodium salt(1-Hydroxyethylidene)bis-phosphonicacidtetrasodiumsalt

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID7029663

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision