Why does CAS 95-25-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 95-25-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 95-25-0?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 95-25-0 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 95-25-0

Q: How do I use CAS 95-25-0 for compliance screening?

Cross-reference CAS 95-25-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 95-25-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 95-25-0

CAS 95-25-0PubChem CID 2733

Chlorzoxazone

Chlorzoxazone is a member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm. It has a role as a sedative and a muscle relaxant. It is an organochlorine compound, a member of 1,3-benzoxazoles and a heteroaryl hydroxy compound. — ChEBI

IUPAC name: 5-chloro-3H-1,3-benzoxazol-2-one

Molecular formula: C7H4ClNO2
Molecular weight: 169.56 g/mol
Exact mass: 168.9930561 Da
XLogP3: 1.8
Topological polar surface area: 38.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Paraflex5-Chloro-2(3H)-benzoxazolone5-Chloro-2-benzoxazolone2(3H)-Benzoxazolone, 5-chloro-5-Chloro-2-benzoxazolinone5-Chlorobenzoxazolidone5-Chloro-2-hydroxybenzoxazole5-Chloro-2-benzoxazolol

16 more reported names

Parafon Forte DSCChlorzoxaneParafonStrifon Forte Dsc2-Hydroxy-5-chlorobenzoxazoleChlorzoxazonumClorzoxazonaStrifon5-chlorobenzoxazolin-2-oneH0DE420U8G5-chloro-2,3-dihydro-1,3-benzoxazol-2-oneCHEBI:3655chlorozoxazoneClorzoxazoneParafon-ForteParafon Dsc

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3655
ChEMBL:CHEMBL1371
EPA DTXSID:DTXSID9022813
PubMed:33814510
PubMed:32142840
PubMed:31501917
PubMed:30503582
PubMed:29555536
PubMed:28762043
PubMed:28689458
PubMed:28438436
PubMed:26739624
PubMed:26599973
PubMed:25956474
PubMed:23669205

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 95-25-0

1 total

Annex

Entry

Chlorzoxazone (INN)

202-403-9

How CAS 95-25-0 is used on this site

CAS 95-25-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 95-25-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 95-25-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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