Why does CAS 94-59-7 appear in more than one EU cosmetic annex?

A substance identified by CAS 94-59-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 94-59-7?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 94-59-7 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 94-59-7

Q: How do I use CAS 94-59-7 for compliance screening?

Cross-reference CAS 94-59-7 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 94-59-7 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 94-59-7

CAS 94-59-7PubChem CID 5144

Safrole

Safrole appears as clear colorless or slightly yellow liquid with the odor of sassafras. Denser than water (density 1.09 g / cm3) and insoluble in water. Hence sinks in water. Obtained from oil of sassafras or oil of camphor. — CAMEO Chemicals

IUPAC name: 5-prop-2-enyl-1,3-benzodioxole

Molecular formula: C10H10O2
Molecular weight: 162.18 g/mol
Exact mass: 162.068079557 Da
XLogP3: 3.0
Topological polar surface area: 18.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

SafrolShikimoleShikomol5-Allyl-1,3-benzodioxoleSafrole MFSafrene1,3-Benzodioxole, 5-(2-propenyl)-Allylcatechol methylene ether

16 more reported names

Shikimol5-(2-Propenyl)-1,3-benzodioxolem-Allylpyrocatechin methylene ether4-Allyl-1,2-methylenedioxybenzene4-Allylpyrocatechol formaldehyde acetalAllylpyrocatechol methylene ether3,4-(Methylenedioxy)allylbenzene1-Allyl-3,4-methylenedioxybenzeneBenzene, 4-allyl-1,2-(methylenedioxy)-Allyldioxybenzene methylene ether1,2-Methylenedioxy-4-allylbenzene1,3-Benzodioxole, 5-allyl-5-(prop-2-en-1-yl)-2H-1,3-benzodioxoleNSC-118313,4-methylenedioxy-allylbenzene3-(3,4-Methylenedioxyphenyl)prop-1-ene

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:8994
ChEMBL:CHEMBL242273
EPA DTXSID:DTXSID0021254
PubMed:25058030
PubMed:23074021
PubMed:22934566
PubMed:22857782
PubMed:22820429
PubMed:22708042
PubMed:22701361
PubMed:22624127
PubMed:22593445
PubMed:22588462
PubMed:22531970
PubMed:22454674

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 94-59-7

1 total

Annex

Entry

360

Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product,…

202-345-4

CMR

How CAS 94-59-7 is used on this site

CAS 94-59-7 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 94-59-7 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 94-59-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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