Why does CAS 70-30-4 appear in more than one EU cosmetic annex?

A substance identified by CAS 70-30-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 70-30-4?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 70-30-4 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 70-30-4

Q: How do I use CAS 70-30-4 for compliance screening?

Cross-reference CAS 70-30-4 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 70-30-4 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 70-30-4

CAS 70-30-4PubChem CID 3598

Hexachlorophene

Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an acaricide, an antibacterial agent, an antiseptic drug and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide. — ChEBI

IUPAC name: 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol

Molecular formula: C13H6Cl6O2
Molecular weight: 406.9 g/mol
Exact mass: 405.846945 Da
XLogP3: 7.5
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

HexachlorofenHexachlorophenNabacpHisoHexExofeneGamophenAlmedermSeptisol

16 more reported names

SurofeneTurgexGerma-MedicaDermadexDistodinGamopheneHexabalmHexophenePhisodanSeptofenSteraskinTersasepticAcigenaFostrilHexafenHexide

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:5693
ChEMBL:CHEMBL496
EPA DTXSID:DTXSID6020690
PubMed:36965607
PubMed:35435491
PubMed:35307375
PubMed:33844597
PubMed:32949729
PubMed:32870474
PubMed:32284327
PubMed:29301063
PubMed:25987361
PubMed:25943520
PubMed:25497112
PubMed:23769903

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 70-30-4

1 total

Annex

Entry

371

2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane (Hexachlorophene (INN))

200-733-8

How CAS 70-30-4 is used on this site

CAS 70-30-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 70-30-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 70-30-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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