Why does CAS 68049-83-2 appear in more than one EU cosmetic annex?

A substance identified by CAS 68049-83-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 68049-83-2?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 68049-83-2 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 68049-83-2

Q: How do I use CAS 68049-83-2 for compliance screening?

Cross-reference CAS 68049-83-2 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 68049-83-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 68049-83-2

CAS 68049-83-2PubChem CID 443029

Azafenidin

Azafenidin is a triazolopyridine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one which is substituted at position 2 by a 2,4-dichloro-5-(prop-2-yn-1-yloxy)phenyl group. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control weeds in fruit crops such as pineapple, citrus, melons, and grapes. Not approved for use within the European Union. It has a role as an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor. It is a dichlorobenzene, a triazolopyridine and a terminal acetylenic compound. — ChEBI

IUPAC name: 2-(2,4-dichloro-5-prop-2-ynoxyphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-one

Molecular formula: C15H13Cl2N3O2
Molecular weight: 338.2 g/mol
Exact mass: 337.0384821 Da
XLogP3: 2.9
Topological polar surface area: 45.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

AzafenidenAzafenidin [ISO]MilestoneEvolusazafenidineUNII-XQK9668H5MXQK9668H5MDPX-R6447

16 more reported names

AZAFENIDIN [MI]CHEBI:29432-(2,4-DICHLORO-5-(2-PROPYNYLOXY)PHENYL)-5,6,7,8-TETRAHYDRO-1,2,4-TRIAZOLO(4,3-A)PYRIDIN-3(2H)-ONE2-(2,4-dichloro-5-prop-2-ynoxy-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-one2-(2,4-DICHLORO-5-PROP-2-YNYLOXYPHENYL)-5,6,7,8-TETRAHYDRO-1,2,4-TRIAZOLO(4,3-A)PYRIDIN-3(2H)-ONE2-(2,4-dichloro-5-prop-2-ynyloxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridin-3(2h)-one2-[2,4-dichloro-5-(prop-2-yn-1-yloxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one2-(2,4-dichloro-5-(prop-2-yn-1-yloxy)phenyl)-5,6,7,8-tetrahydro(1,2,4)triazolo(4,3-a)pyridin-3(2H)-one2-(2,4-dichloro-5-prop-2-ynoxy-phenyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyridin-3-oneRefChem:115929AC1L9DWEAzafenidin 100 microg/mL in AcetonitrileAzafenidin Solution in Methanol, 100_g/mL1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(2,4-dichloro-5-(2-propynyloxy)phenyl)-5,6,7,8-tetrahydro-2-[2,4-dichloro-5-(2-propynyloxy)phenyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]-pyridin-3(2H)-one2-[2,4-Dichloro-5-(2-propynyloxy)phenyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine-3(2H) -one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:2943
EPA DTXSID:DTXSID2034205
PubMed:18943113
PubMed:17512650

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 68049-83-2

1 total

Annex

Entry

1157

Azafenidin (ISO)

620-425-0

CMR

How CAS 68049-83-2 is used on this site

CAS 68049-83-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 68049-83-2 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 68049-83-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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