Why does CAS 61-75-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 61-75-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 61-75-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 61-75-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 61-75-6

Q: How do I use CAS 61-75-6 for compliance screening?

Cross-reference CAS 61-75-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 61-75-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS number Browse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 61-75-6

CAS 61-75-6PubChem CID 6100

Bretylium Tosylate

Bretylium tosylate is the tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. It has a role as an antihypertensive agent, an adrenergic antagonist and an anti-arrhythmia drug. It is a quaternary ammonium salt and an organosulfonate salt. It contains a bretylium. — ChEBI

IUPAC name: (2-bromophenyl)methyl-ethyl-dimethylazanium;4-methylbenzenesulfonate

Molecular formula: C18H24BrNO3S
Molecular weight: 414.4 g/mol
Exact mass: 413.06603 Da
Topological polar surface area: 65.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 2
Defined stereocentres: 0

Also known as

BretylolBretylium tosilateDarentinTosilato de bretilioTosilate de bretyliumBretylii tosilasASL-603(o-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate

16 more reported names

Bretilio tosilatoBretylium Tosylate In Dextrose 5%NSC-621642-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-methylbenzenesulfonateDimethylethyl-o-bromobenzylammonium-p-toluenesulphonateN-Ethyl-N-o-bromobenzyl-N,N-dimethylammonium tosylate78ZP3YR353Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1)CHEBI:3173BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERbrAtylium (cation)RefChem:56963C01BD02200-516-8OrnidBretylate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3173
ChEMBL:CHEMBL1095292
EPA DTXSID:DTXSID1022685
PubMed:21599003
PubMed:15226788
PubMed:9085344
PubMed:7447102
PubMed:7235792
PubMed:6858846
PubMed:6600915
PubMed:5417842
PubMed:4911756
PubMed:4553611
PubMed:4079442
PubMed:3795968

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 61-75-6

1 total

Annex

Entry

Bretylium tosilate (INN)

200-516-8

How CAS 61-75-6 is used on this site

CAS 61-75-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 61-75-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 61-75-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 61-75-6 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 61-75-6 in your documentation.