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CAS 569646-79-3

CAS 569646-79-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 569646-79-3
CAS 569646-79-3PubChem CID 45094126

4-(3-Ethoxy-4-hydroxyphenyl)-2-butanone

Ethylzingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by ethoxy and hydroxy groups, respectively. It is a preservative with antimicrobial activity and a good safety profile that has been approved for use in cosmetics. It is structurally similar to zingerone, a phytochemical found in the root of the ginger plant Zingiber officinale. It has a role as an antimicrobial cosmetic preservative, an antibacterial agent and an antifungal agent. It is a member of phenols, an aromatic ether and a methyl ketone. — ChEBI

IUPAC name
4-(3-ethoxy-4-hydroxyphenyl)butan-2-one
Molecular formula
C12H16O3
Molecular weight
208.25 g/mol
Exact mass
208.109944368 Da
XLogP3
1.2
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

ethylzingeroneUNII-TH7XI54W45TH7XI54W452-Butanone, 4-(3-ethoxy-4-hydroxyphenyl)-CHEBI:172922RefChem:97147HYDROXYETHOXYPHENYL BUTANONE2-Butanone,4-(3-ethoxy-4-hydroxyphenyl)-(7CI)
4 more reported names
Hydroxyethoxyphenyl butanone [INCI]4-(3-ethoxy-4-hydroxy-phenyl)butan-2-oneCS-0256997EN300-65784
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 569646-79-3

1 total
Annex
V
Entry
60

HYDROXYETHOXY­PHENYL BUTANONE, HEPB

4-(3-ethoxy-4-hy­droxyphenyl)bu­tan-2-one

Allowed for use as a preservative in rinse off, oral care and leave-on cosmetic products at a maximum concentration of 0,7 % in ready for use preparation.

EC
933-435-8
Max concentration

How CAS 569646-79-3 is used on this site

CAS 569646-79-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 569646-79-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 569646-79-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.
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