Why does CAS 302-40-9 appear in more than one EU cosmetic annex?

A substance identified by CAS 302-40-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 302-40-9?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 302-40-9 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 302-40-9

Q: How do I use CAS 302-40-9 for compliance screening?

Cross-reference CAS 302-40-9 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 302-40-9 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 302-40-9

CAS 302-40-9PubChem CID 9330

Benactyzine

2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester is a diarylmethane. — ChEBI

IUPAC name: 2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate

Molecular formula: C20H25NO3
Molecular weight: 327.4 g/mol
Exact mass: 327.18344366 Da
XLogP3: 2.6
Topological polar surface area: 49.8 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

BenactyzinBenzactyzine2-Diethylaminoethyl benzilateBenacticinaBenactizinaDiethylaminoethyl benzilateBenactyzinumBenzilic acid, 2-(diethylamino)ethyl ester

16 more reported names

Benzilic acid beta-diethylaminoethyl ester595EG71R3FBenzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl esterRefChem:561233206-123-82-(Diethylamino)ethyl benzilate2-(Diethylamino)ethyl hydroxy(diphenyl)acetate2-(Diethylamino)ethyl diphenylglycolateDiphenylglycolic acid 2-(diethylamino)ethyl esterBenactyzine (INN)BENACTYZINE [INN]Benactizina [DCIT]Benactizina [Italian]Benactyzine [INN:BAN]Benactyzinum [INN-Latin]Benacticina [INN-Spanish]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:94775
ChEMBL:CHEMBL70352
EPA DTXSID:DTXSID0022644
PubMed:28551711
PubMed:27655295
PubMed:22384146
PubMed:21218100
PubMed:20445738
PubMed:20223132
PubMed:19689278
PubMed:19453088
PubMed:19430975
PubMed:18680758
PubMed:18669363
PubMed:18384867

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 302-40-9

1 total

Annex

Entry

157

Benactyzine (INN)

206-123-8

How CAS 302-40-9 is used on this site

CAS 302-40-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 302-40-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 302-40-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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