Why does CAS 283159-90-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 283159-90-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 283159-90-0 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 283159-90-0

Q: How do I use CAS 283159-90-0 for compliance screening?

Cross-reference CAS 283159-90-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 283159-90-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 283159-90-0

CAS 283159-90-0PubChem CID 11338509

Valifenalate

Valifenalate is a diastereoisomeric mixture of L-(R)- and L-(S)-valifenalate. An anti-peronosporic fungicide, it is used to control mildew in many crops including grapes, potatoes and tomatoes. It has a role as an antifungal agrochemical. It is a diastereoisomeric mixture and an acylamino acid fungicide. It contains a L-(R)-valifenalate and a L-(S)-valifenalate. — ChEBI

IUPAC name: methyl 3-(4-chlorophenyl)-3-[[(2S)-3-methyl-2-(propan-2-yloxycarbonylamino)butanoyl]amino]propanoate

Molecular formula: C19H27ClN2O5
Molecular weight: 398.9 g/mol
Exact mass: 398.1608497 Da
XLogP3: 3.4
Topological polar surface area: 93.7 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 1

Also known as

ValiphenalValifenalate [ISO]S4BR27QQ5SIR 5885CHEBI:83610methyl 3-(4-chlorophenyl)-3-{[N-(isopropoxycarbonyl)-L-valyl]amino}propanoatemethyl N-(isopropoxycarbonyl)-L-valyl-3-(4-chlorophenyl)-beta-alaninatemethyl N-(isopropoxycarbonyl)-L-valyl-3-(p-chlorophenyl)-beta-alaninate

16 more reported names

methyl N-[(1-methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)-beta-alaninatebeta-Alanine, N-((1-methylethoxy)carbonyl)-L-valyl-3-(4-chlorophenyl)-, methyl esterMETHYL (3RS)-3-(4-CHLOROPHENYL)-N-(N-(ISOPROPOXYCARBONYL)-L-VALYL)-.BETA.-ALANINATEMethyl (3RS)-3-(4-chlorophenyl)-N-(N-(isopropoxycarbonyl)-L-valyl)-beta-alaninateMETHYL 3-(4-CHLOROPHENYL)-N-(((1-METHYLETHOXY)CARBONYL)-L-VALYL)-.BETA.-ALANINATEMethyl 3-(4-chlorophenyl)-N-(((1-methylethoxy)carbonyl)-L-valyl)-beta-alaninate.BETA.-ALANINE, N-((1-METHYLETHOXY)CARBONYL)-L-VALYL-3-(4-CHLOROPHENYL)-, METHYL ESTERbeta-Alanine, N-[(1-methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)-, methyl estermethyl 3-(4-chlorophenyl)-3-((N-(isopropoxycarbonyl)-L-valyl)amino)propanoatemethyl N-((1-methylethoxy)carbonyl)-L-valyl-3-(4-chlorophenyl)-beta-alaninateN-((1-methylethoxy)carbonyl)-L-valyl-3-(4-chlorophenyl)-b-Alanine, methyl esterN-[(1-methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)-b-Alanine, methyl esterRefChem:193580608-192-3IR5885;ValiphenalC19H27ClN2O5

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:83610
EPA DTXSID:DTXSID6058051

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 283159-90-0

1 total

Annex

Entry

1706

methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate

608-192-3

How CAS 283159-90-0 is used on this site

CAS 283159-90-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 283159-90-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 283159-90-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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