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Annex II Entry 1706 24/08/2023

methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate

methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1706

Chemical identity and properties

PubChem 2D chemical structure for CAS 283159-90-0
CAS 283159-90-0PubChem CID 11338509

Valifenalate

Valifenalate is a diastereoisomeric mixture of L-(R)- and L-(S)-valifenalate. An anti-peronosporic fungicide, it is used to control mildew in many crops including grapes, potatoes and tomatoes. It has a role as an antifungal agrochemical. It is a diastereoisomeric mixture and an acylamino acid fungicide. It contains a L-(R)-valifenalate and a L-(S)-valifenalate. — ChEBI

IUPAC name
methyl 3-(4-chlorophenyl)-3-[[(2S)-3-methyl-2-(propan-2-yloxycarbonylamino)butanoyl]amino]propanoate
Molecular formula
C19H27ClN2O5
Molecular weight
398.9 g/mol
Exact mass
398.1608497 Da
XLogP3
3.4
Topological polar surface area
93.7 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
1

Also known as

ValiphenalValifenalate [ISO]S4BR27QQ5SIR 5885CHEBI:83610methyl 3-(4-chlorophenyl)-3-{[N-(isopropoxycarbonyl)-L-valyl]amino}propanoatemethyl N-(isopropoxycarbonyl)-L-valyl-3-(4-chlorophenyl)-beta-alaninatemethyl N-(isopropoxycarbonyl)-L-valyl-3-(p-chlorophenyl)-beta-alaninate
16 more reported names
methyl N-[(1-methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)-beta-alaninatebeta-Alanine, N-((1-methylethoxy)carbonyl)-L-valyl-3-(4-chlorophenyl)-, methyl esterMETHYL (3RS)-3-(4-CHLOROPHENYL)-N-(N-(ISOPROPOXYCARBONYL)-L-VALYL)-.BETA.-ALANINATEMethyl (3RS)-3-(4-chlorophenyl)-N-(N-(isopropoxycarbonyl)-L-valyl)-beta-alaninateMETHYL 3-(4-CHLOROPHENYL)-N-(((1-METHYLETHOXY)CARBONYL)-L-VALYL)-.BETA.-ALANINATEMethyl 3-(4-chlorophenyl)-N-(((1-methylethoxy)carbonyl)-L-valyl)-beta-alaninate.BETA.-ALANINE, N-((1-METHYLETHOXY)CARBONYL)-L-VALYL-3-(4-CHLOROPHENYL)-, METHYL ESTERbeta-Alanine, N-[(1-methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)-, methyl estermethyl 3-(4-chlorophenyl)-3-((N-(isopropoxycarbonyl)-L-valyl)amino)propanoatemethyl N-((1-methylethoxy)carbonyl)-L-valyl-3-(4-chlorophenyl)-beta-alaninateN-((1-methylethoxy)carbonyl)-L-valyl-3-(4-chlorophenyl)-b-Alanine, methyl esterN-[(1-methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)-b-Alanine, methyl esterRefChem:193580608-192-3IR5885;ValiphenalC19H27ClN2O5
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate

Regulatory information

Regulation

(EU) 2023/1490

See every entry this act set

Key data

CAS
283159-90-0
EC
608-192-3
Annex
II
Entry number
1706

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1703
Nearby record in the same annex

Benzophenone

CAS: 119-61-9
EC: 204-337-6

What Annex II means for methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate

methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 283159-90-0 is the unique numerical identifier assigned to methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate

This page summarizes one Annex II record for methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate, but confirm any final regulatory decision against the current official annex wording and source files.

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