Why does CAS 23564-05-8 appear in more than one EU cosmetic annex?

A substance identified by CAS 23564-05-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 23564-05-8?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 23564-05-8 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 23564-05-8

Q: How do I use CAS 23564-05-8 for compliance screening?

Cross-reference CAS 23564-05-8 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 23564-05-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 23564-05-8

CAS 23564-05-8PubChem CID 3032791

Thiophanate-Methyl

Thiophanate-methyl is a member of the class of thioureas that is the dimethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould. It has a role as an antifungal agrochemical. It is a carbamate ester, a member of thioureas, a benzimidazole precursor fungicide and a carbamate fungicide. It is functionally related to a 1,2-phenylenediamine. — ChEBI

IUPAC name: methyl N-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate

Molecular formula: C12H14N4O4S2
Molecular weight: 342.4 g/mol
Exact mass: 342.04564729 Da
XLogP3: 2.6
Topological polar surface area: 165.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

MethylthiofanateTHIOPHANATE METHYLThiophanate MMethyl topsinMethylthiophanateMildothaneNeotopsinMethyl thiophanate

16 more reported names

FungoCercobin methylTopsin MethylCaligranMetobenEnovit methylEnovit MTopsin MCycosinEasoutThiopanEnovit SuperCercobin MTopsin NF-44SipcaplantSipcasan

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:35014
ChEMBL:CHEMBL487187
EPA DTXSID:DTXSID1024338
PubMed:22912890
PubMed:22821740
PubMed:22667099
PubMed:22471787
PubMed:22396740
PubMed:22393693
PubMed:22376006
PubMed:22330093
PubMed:22291484
PubMed:22290833
PubMed:22250759
PubMed:22238633

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 23564-05-8

1 total

Annex

Entry

1047

Thiophanate-methyl

245-740-7

CMR

How CAS 23564-05-8 is used on this site

CAS 23564-05-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 23564-05-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 23564-05-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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