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Annex II Entry 1047 CMR15/10/2010

Thiophanate-methyl

Thiophanate-methyl is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1047
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 23564-05-8
CAS 23564-05-8PubChem CID 3032791

Thiophanate-Methyl

Thiophanate-methyl is a member of the class of thioureas that is the dimethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould. It has a role as an antifungal agrochemical. It is a carbamate ester, a member of thioureas, a benzimidazole precursor fungicide and a carbamate fungicide. It is functionally related to a 1,2-phenylenediamine. — ChEBI

IUPAC name
methyl N-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate
Molecular formula
C12H14N4O4S2
Molecular weight
342.4 g/mol
Exact mass
342.04564729 Da
XLogP3
2.6
Topological polar surface area
165.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
0

Also known as

MethylthiofanateTHIOPHANATE METHYLThiophanate MMethyl topsinMethylthiophanateMildothaneNeotopsinMethyl thiophanate
16 more reported names
FungoCercobin methylTopsin MethylCaligranMetobenEnovit methylEnovit MTopsin MCycosinEasoutThiopanEnovit SuperCercobin MTopsin NF-44SipcaplantSipcasan
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Thiophanate-methyl

Chemical / IUPAC name

1,2-di-(3-methoxycarbonyl-2-thioureido)benzene

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2—✓—

Key data

CAS
23564-05-8
EC
245-740-7
Annex
II
Entry number
1047

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1049
Nearby record in the same annex

Propyzamide

CAS: 23950-58-5
EC: 245-951-4
Annex II 1044
Nearby record in the same annex

Di-allate

CAS: 2303-16-4
EC: 218-961-1
Annex II 1052
Nearby record in the same annex

Chinomethionate

CAS: 2439-01-2
EC: 219-455-3

What Annex II means for Thiophanate-methyl

Thiophanate-methyl is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Thiophanate-methyl is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 23564-05-8 is the unique numerical identifier assigned to Thiophanate-methyl by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Thiophanate-methyl has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Thiophanate-methyl

This page summarizes one Annex II record for Thiophanate-methyl from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Thiophanate-methyl, but confirm any final regulatory decision against the current official annex wording and source files.

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