Why does CAS 1464-53-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 1464-53-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 1464-53-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 1464-53-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 1464-53-5

Q: How do I use CAS 1464-53-5 for compliance screening?

Cross-reference CAS 1464-53-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 1464-53-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1464-53-5

CAS 1464-53-5PubChem CID 11254

Diepoxybutane

Diepoxybutane is an epoxide. It has a role as a mutagen. — ChEBI

IUPAC name: 2-(oxiran-2-yl)oxirane

Molecular formula: C4H6O2
Molecular weight: 86.09 g/mol
Exact mass: 86.036779430 Da
XLogP3: -0.5
Topological polar surface area: 25.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

1,3-Butadiene diepoxide2,2'-BioxiraneButadiene diepoxideDioxybutadieneBioxirane1,2:3,4-DIEPOXYBUTANEButane diepoxideButadiene dioxide

16 more reported names

BioxiranButadiendioxyd1,2:3,4-Butadiene diepoxideButane, 1,2:3,4-diepoxy-1,1'-Bi(ethylene oxide)ENT-26592CB 1181NSC 629Threitol, 1,2:3,4-dianhydro-1,1'-Bi[ethylene oxide]R 181M 883860OB65YNABNSC629CHEBI:23704NSC-629

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:23704
ChEMBL:CHEMBL1964283
EPA DTXSID:DTXSID0041307
PubMed:22772369
PubMed:22701786
PubMed:22698567
PubMed:22693659
PubMed:22675616
PubMed:22675615
PubMed:22670845
PubMed:22591656
PubMed:22532920
PubMed:22405976
PubMed:22373003
PubMed:22345984

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 1464-53-5

1 total

Annex

Entry

662

2,2'-Bioxirane (1,2:3,4-Diepoxybutane)

215-979-1

CMR

How CAS 1464-53-5 is used on this site

CAS 1464-53-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 1464-53-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 1464-53-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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