Why does CAS 146-48-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 146-48-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 146-48-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 146-48-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 146-48-5

Q: How do I use CAS 146-48-5 for compliance screening?

Cross-reference CAS 146-48-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 146-48-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 146-48-5

CAS 146-48-5PubChem CID 8969

Yohimbine

Yohimbine is an indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina. It has a role as a dopamine receptor D2 antagonist, an alpha-adrenergic antagonist and a serotonergic antagonist. It is functionally related to a yohimbic acid. — ChEBI

IUPAC name: methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

Molecular formula: C21H26N2O3
Molecular weight: 354.4 g/mol
Exact mass: 354.19434270 Da
XLogP3: 2.9
Topological polar surface area: 65.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 5

Also known as

YohimbinQuebrachineCorynineQuebrachinAPHRODINEYohimbic acid methyl ester(+)-YohimbineYohimbinum

16 more reported names

17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester2Y49VWD90Q(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl esterYohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-CHEBI:10093methyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylatemethyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo(11.8.0.0^(2,10).0^(4,9).0^(15,20))henicosa-2(10),4,6,8-tetraene-19-carboxylateTartrate, CorynanthineRefChem:56477205-672-0AphrosolJohimbin17-Hydroxyyohimban-16-carboxylic acid methyl estermethyl 17alpha-hydroxyyohimban-16alpha-carboxylateActibineYOHIMBINE CHLORIDE

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:10093
ChEMBL:CHEMBL15245
EPA DTXSID:DTXSID9040130
PubMed:35224877
PubMed:28333344
PubMed:25080296
PubMed:23113301
PubMed:23071064
PubMed:23035904
PubMed:22952481
PubMed:22950315
PubMed:22940018
PubMed:22917679
PubMed:22890081
PubMed:22884868

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 146-48-5

1 total

Annex

Entry

337

Yohimbine and its salts

205-672-0

How CAS 146-48-5 is used on this site

CAS 146-48-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 146-48-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 146-48-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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