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CAS 1 record

CAS 127-06-0

CAS 127-06-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 127-06-0
CAS 127-06-0PubChem CID 67180

Acetone, oxime

Acetone oxime is a ketoxime. — ChEBI

IUPAC name
N-propan-2-ylidenehydroxylamine
Molecular formula
C3H7NO
Molecular weight
73.09 g/mol
Exact mass
73.052763847 Da
XLogP3
0.1
Topological polar surface area
32.6 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Acetone oximeAcetoxime2-Propanone, oximeAcetonoxime2-Propanone oximebeta-IsonitrosopropaneQX74TFD64TNSC-7601
16 more reported names
CHEBI:15349actone oximeRefChem:914970DTXCID1010204-820-1propan-2-one oximepropanone oxime.beta.-Isonitrosopropanepropan-2-oneoximeN-(propan-2-ylidene)hydroxylaminePropan-2-one oxime(Chunks or pellets)propane, 2-hydroxyimino-CCRIS 5NSC 7601EINECS 204-820-1UNII-QX74TFD64T
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match67180

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H228 (99.3%): Flammable solid [Danger Flammable solids]; H312 (80.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H317 (94.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (96.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H351 (81.6%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P240, P241, P261, P264+P265, P272, P280, P302+P352, P305+P354+P338, P317, P318, P321, P333+P317, P362+P364, P370+P378, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 152 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H228: Flammable solid [Danger Flammable solids]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P203, P210, P240, P241, P261, P264+P265, P272, P280, P302+P352, P305+P354+P338, P317, P318, P321, P333+P317, P362+P364, P370+P378, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Acetoxime is a solid. It is used in organic synthesis (intermediate), as a solvent for cellulose ethers, and as a primer for diesel fuels. HUMAN STUDIES: Acetoxime has been tested in vitro as an experimental medication for herpes infection. ANIMAL STUDIES: Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female rats. The dose of 1.0 g/liter was administered 5 days/week for 18 months (total dose, 6.2 -7.0 g/rat). Acetoxime induced benign hepatocellular adenomas in 80% of the males but did not produce tumors in the females. The 90 day-NOAEL of the test substance in rats by the oral route was 15 mg/kg bw/day in both sexes. No effects were observed in the reproductive organs or tissues up to the highest dose tested (50 mg/kg bw/day). Acetoxime was negative in the Ames test with TA97, TA98, TA100 and TA1535 with and without metabolic activation. Acetoxime was genotoxic in Drosophila melanogaster. When tested in vivo acetoxime was found to induce a specific pattern of base damage in rat liver DNA and RNA, including the induction of increased levels of 8-hydroxyguanine. Because acetoxime was a weaker carcinogen in Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for acetoxime(SRC), using a log Kow of 0.12(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.3(SRC), determined from a log Kow of 0.12(2) and a regression-derived equation(3), indicates that acetoxime is expected to have very high mobility in soil(SRC). The pKa of acetoxime is 12.42(4), indicating that this compound will exist as its neutral species in the environment (pH 5-9). Volatilization of acetoxime from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.8X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Acetoxime is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.82 mm Hg at 25 °C(5). A 0% of theoretical BOD using domestic sewage in the Closed Bottle test(6) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.3(SRC), determined from a log Kow of 0.12(2) and a regression-derived equation(3), indicates that acetoxime is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 7.8X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Using this Henry's Law constant and an estimation method(5), volatilization half-lives for a model river and model lake are 4 days and 33 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low. A 0% of theoretical BOD using domestic sewage in the Closed Bottle test(7) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acetoxime, which has a vapor pressure of 1.82 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase acetoxime is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 48 days(SRC), calculated from its rate constant of 3.3X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Acetoxime does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 127-06-0

1 total

How CAS 127-06-0 is used on this site

CAS 127-06-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 127-06-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

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A substance identified by CAS 127-06-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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