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Annex II Entry 8 17/10/2010

Cinchophen (INN), its salts, derivatives and salts of these derivatives

Cinchophen (INN), its salts, derivatives and salts of these derivatives is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 8

Chemical identity and properties

PubChem 2D chemical structure for CAS 132-60-5
CAS 132-60-5PubChem CID 8593

Cinchophen

2-phenyl-4-quinolinecarboxylic acid is a member of quinolines. — ChEBI

IUPAC name
2-phenylquinoline-4-carboxylic acid
Molecular formula
C16H11NO2
Molecular weight
249.26 g/mol
Exact mass
249.078978594 Da
XLogP3
3.4
Topological polar surface area
50.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2-Phenyl-4-quinolinecarboxylic acid2-Phenylcinchoninic acidAgotanAtophanCinchophenePhenoquinQuinophanQuinophen
16 more reported names
CinconalQuinofenTervalonMylofanolRhematanTophosanAlutylAtocinRheuminTopholVantylViophanArtamAciphenochinolineCinchophenic acidAciphenochinolinium
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 5949-18-8
CAS 5949-18-8PubChem CID 23691042

Cinchophen sodium

IUPAC name
sodium 2-phenylquinoline-4-carboxylate
Molecular formula
C16H10NNaO2
Molecular weight
271.24 g/mol
Exact mass
271.06092284 Da
Topological polar surface area
53.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
2
Defined stereocentres
0

Also known as

Cinchophen sodium saltAtophan sodiumAtophan-natriumCinchophen, sodium saltAtophan-natrium [German]EINECS 227-710-5UNII-454ZOQ4L8NSodium 2-phenyl-4-quinolinecarboxylate
9 more reported names
454ZOQ4L8N2-PHENYLCINCHONINIC ACID SODIUM SALTRefChem:200185227-710-5Sodium cinchophenSodium 2-phenylcinchoninateCINCHONINIC ACID, 2-PHENYL-, SODIUM SALT4-Quinolinecarboxylic acid, 2-phenyl-, sodium saltZSOINCKGNIMAEG-UHFFFAOYSA-M
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Cinchophen (INN), its salts, derivatives and salts of these derivatives

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
132-60-5 / 5949-18-8
EC
205-067-1 / 227-710-5
Annex
II
Entry number
8

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Cinchophen (INN), its salts, derivatives and salts of these derivatives

Cinchophen (INN), its salts, derivatives and salts of these derivatives is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Cinchophen (INN), its salts, derivatives and salts of these derivatives is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 132-60-5 / 5949-18-8 is the unique numerical identifier assigned to Cinchophen (INN), its salts, derivatives and salts of these derivatives by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Cinchophen (INN), its salts, derivatives and salts of these derivatives

This page summarizes one Annex II record for Cinchophen (INN), its salts, derivatives and salts of these derivatives from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cinchophen (INN), its salts, derivatives and salts of these derivatives, but confirm any final regulatory decision against the current official annex wording and source files.

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