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Annex II Entry 7 17/10/2010

Aminocaproic acid (INN) and its salts

Aminocaproic acid (INN) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 7

Chemical identity and properties

PubChem 2D chemical structure for CAS 60-32-2
CAS 60-32-2PubChem CID 564

6-Aminohexanoic Acid

6-aminohexanoic acid is an -amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as a metabolite, an antifibrinolytic drug and a hematologic agent. It is an epsilon-amino acid and an omega-amino fatty acid. It is functionally related to a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion. — ChEBI

IUPAC name
6-aminohexanoic acid
Molecular formula
C6H13NO2
Molecular weight
131.17 g/mol
Exact mass
131.094628657 Da
XLogP3
-3.0
Topological polar surface area
63.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

6-Aminocaproic acidaminocaproic acidHexanoic acid, 6-amino-AcepramineEpsicapronEpsilcapraminCapramolCaprolisin
16 more reported names
AcepraminHemoparIpsilonRespraminAmikarEACAAminokapronAfibrinCaplaminAtseminCapracidHepinEACSEpsilon Sepsilon-Leucineepsilcapramine
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Aminocaproic acid (INN) and its salts

Regulatory information

Regulation

(EC) 2009/1223

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Identified ingredients

Key data

CAS
60-32-2
EC
200-469-3
Annex
II
Entry number
7

Inventory links for Aminocaproic acid (INN) and its salts

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Aminocaproic acid (INN) and its salts

Aminocaproic acid (INN) and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Aminocaproic acid (INN) and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 60-32-2 is the unique numerical identifier assigned to Aminocaproic acid (INN) and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Aminocaproic acid (INN) and its salts

This page summarizes one Annex II record for Aminocaproic acid (INN) and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Aminocaproic acid (INN) and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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