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Annex II Entry 646 CMR15/10/2010

1,2-Dibromo-3-chloropropane

1,2-Dibromo-3-chloropropane is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 646
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 96-12-8
CAS 96-12-8PubChem CID 7280

1,2-Dibromo-3-Chloropropane

1,2-Dibromo-3-chloropropane is a manufactured chemical and is not found naturally in the environment. It is a colorless liquid with a sharp smell. It can be tasted in water at very low concentrations. Some industries use it to make another chemical that is used to make materials that resist burning. Large amounts of 1,2-dibromo-3-chloropropane were used in the past on certain farms to kill pests that harmed crops. Farmers in all states other than Hawaii stopped using this chemical in 1979. Hawaii stopped using it in 1985. We do not know exactly how much of it is currently made or used by industry, but it is probably a small amount. — Agency for Toxic Substances and Disease Registry (ATSDR)

IUPAC name
1,2-dibromo-3-chloropropane
Molecular formula
C3H5Br2Cl
Molecular weight
236.33 g/mol
Exact mass
235.84260 Da
XLogP3
2.4
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

DBCP3-Chloro-1,2-dibromopropaneFumazoneNemagonDibromochloropropaneNemafumeNemapazNemazon
16 more reported names
NemabromNemanaxNemasetFumagonFumazone 86Nemagon 20Nemagon 90Nemagon 20GNemagon Soil FumigantNemagoneNematoxFumazone 86EDibromchlorpropanFumazon 86Nemanex1-Chloro-2,3-dibromopropane
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,2-Dibromo-3-chloropropane

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1A——✓
Cat. 1B✓✓—

Key data

CAS
96-12-8
EC
202-479-3
Annex
II
Entry number
646

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 644
Nearby record in the same annex

2-Bromopropane

CAS: 75-26-3
EC: 200-855-1
Annex II 643
Nearby record in the same annex

Chrysene

CAS: 218-01-9
EC: 205-923-4

What Annex II means for 1,2-Dibromo-3-chloropropane

1,2-Dibromo-3-chloropropane is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 1,2-Dibromo-3-chloropropane is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 96-12-8 is the unique numerical identifier assigned to 1,2-Dibromo-3-chloropropane by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

1,2-Dibromo-3-chloropropane has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1,2-Dibromo-3-chloropropane

This page summarizes one Annex II record for 1,2-Dibromo-3-chloropropane from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1,2-Dibromo-3-chloropropane, but confirm any final regulatory decision against the current official annex wording and source files.

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