Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 444 20/10/2010

1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient

1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 444

Chemical identity and properties

PubChem 2D chemical structure for CAS 104-27-8
CAS 104-27-8PubChem CID 5803450

1-(4-Methoxyphenyl)-1-penten-3-one

IUPAC name
(E)-1-(4-methoxyphenyl)pent-1-en-3-one
Molecular formula
C12H14O2
Molecular weight
190.24 g/mol
Exact mass
190.099379685 Da
XLogP3
2.5
Topological polar surface area
26.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

1-(4-Methoxyphenyl)pent-1-en-3-one1-Penten-3-one, 1-(4-methoxyphenyl)-(1E)-1-(4-methoxyphenyl)pent-1-en-3-oneRefChem:592708alpha-Methylanisalacetone1-(p-METHOXYPHENYL)-1-PENTEN-3-ONEEthyl p-methoxystyryl ketoneFEMA No. 2673
16 more reported names
1-Penten-3-one, 1-(p-methoxyphenyl)-U0ZZO1ACOR1-Penten-3-one, 1-(4-methoxyphenyl)-, (1E)-NSC-133448A-METHYLANISALACETONEalpha-MethylanisylideneacetoneMethoxystyryl ethyl ketone, p-UNII-U0ZZO1ACOREINECS 203-190-5NSC 133448BRN 31971371-p-Methoxyphenylpent-1-en-3-oneETHONE [FCC]4-08-00-00911 (Beilstein Handbook Reference)FEMA 2673MSK2620
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5803450

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 35.5% (54 of 152) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (64.5%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 152 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 54 of 152 reports by companies.; There is 1 notification provided by 98 of 152 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Key data

CAS
104-27-8
EC
203-190-5
Annex
II
Entry number
444

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient

1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 104-27-8 is the unique numerical identifier assigned to 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient

This page summarizes one Annex II record for 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare 1-(4-Methoxyphenyl)-1-pentene-3-one (alpha-Methylanisylideneacetone), when used as a fragrance ingredient side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II