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Annex II Entry 442 20/10/2010

7-Methoxycoumarin, when used as a fragrance ingredient

7-Methoxycoumarin, when used as a fragrance ingredient is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 442

Chemical identity and properties

PubChem 2D chemical structure for CAS 531-59-9
CAS 531-59-9PubChem CID 10748

Methylumbelliferone

Herniarin is a member of the class of coumarins that is coumarin substituted by a methoxy group at position 7. It has a role as a fluorochrome. — ChEBI

IUPAC name
7-methoxychromen-2-one
Molecular formula
C10H8O3
Molecular weight
176.17 g/mol
Exact mass
176.047344113 Da
XLogP3
1.9
Topological polar surface area
35.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

7-MethoxycoumarinHerniarin7-Methoxy-2H-chromen-2-oneAyapaninHerniarine7-Methoxy-2H-1-benzopyran-2-one2H-1-BENZOPYRAN-2-ONE, 7-METHOXY-DGK72G008A
16 more reported names
NSC-404559CHEBI:5679RefChem:25893208-513-3Coumarin, 7-methoxy-Methyl umbelliferyl etherMETHOXYCOURMARIN, 7-7-methoxy-chromen-2-one7-methoxy-coumarin7-Methoxy CoumarinNSC 404559BRN 01417287-(methyloxy)-2H-chromen-2-one7-Methyl ether derivative of UmbelliferoneKBio2_003440HY-N1366
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

7-Methoxycoumarin, when used as a fragrance ingredient

Regulatory information

Regulation

(EC) 2009/1223

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SCCS opinions

Key data

CAS
531-59-9
EC
208-513-3
Annex
II
Entry number
442

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 7-Methoxycoumarin, when used as a fragrance ingredient

7-Methoxycoumarin, when used as a fragrance ingredient is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 7-Methoxycoumarin, when used as a fragrance ingredient is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 531-59-9 is the unique numerical identifier assigned to 7-Methoxycoumarin, when used as a fragrance ingredient by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 7-Methoxycoumarin, when used as a fragrance ingredient

This page summarizes one Annex II record for 7-Methoxycoumarin, when used as a fragrance ingredient from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 7-Methoxycoumarin, when used as a fragrance ingredient, but confirm any final regulatory decision against the current official annex wording and source files.

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