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Annex II Entry 177 20/10/2010

Tolboxane (INN)

Tolboxane (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 177

Chemical identity and properties

PubChem 2D chemical structure for CAS 2430-46-8
CAS 2430-46-8PubChem CID 72134

Tolboxane

Tolboxane is a small molecule drug. The usage of the INN stem '-oxan(e)' in the name indicates that Tolboxane is a benzodioxane derivative. Tolboxane has a monoisotopic molecular weight of 232.16 Da. — DrugBank

IUPAC name
5-methyl-2-(4-methylphenyl)-5-propyl-1,3,2-dioxaborinane
Molecular formula
C14H21BO2
Molecular weight
232.13 g/mol
Exact mass
232.1634601 Da
Topological polar surface area
18.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

ClarphorilDiossoboronoClarmilTolboxanTolboxanumTolboxane [INN:DCF]Tolboxanum [INN-Latin]Tolboxano
16 more reported names
IS 813Tolboxano [INN-Spanish]JS 8135-Methyl-5-propyl-2-(p-tolyl)-1,3,2-dioxaborinaneNSC 169422UNII-33P8JV23L7BRN 051740033P8JV23L7TOLBOXANE [INN]2-Methyl-2-propyl-1,3-propanediol-p-methylbenzeneboronateNSC-169422p-Tolueneboronic acid, cyclic 2-methyl-2-propyltrimethylene ester1,3,2-Dioxaborinane, 5-methyl-5-propyl-2-p-tolyl-1,3,2-Dioxaborinane, 5-methyl-2-(4-methylphenyl)-5-propyl-Tolboxanum (INN-Latin)Tolboxano (INN-Spanish)
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Tolboxane (INN)

Chemical / IUPAC name

p-Tolueneboronic acid, cyclic 2-methyl-2-propyltrimethylene ester

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
2430-46-8
EC
—
Annex
II
Entry number
177

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 180
Nearby record in the same annex

Fenozolone (INN)

CAS: 15302-16-6
EC: 239-339-6
Annex II 182
Nearby record in the same annex

Ethylene oxide

CAS: 75-21-8
EC: 200-849-9

What Annex II means for Tolboxane (INN)

Tolboxane (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Tolboxane (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 2430-46-8 is the unique numerical identifier assigned to Tolboxane (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Tolboxane (INN)

This page summarizes one Annex II record for Tolboxane (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Tolboxane (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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