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Annex II Entry 1652 21/06/2021

Diisohexyl phthalate

Diisohexyl phthalate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1652

Chemical identity and properties

PubChem 2D chemical structure for CAS 71850-09-4
CAS 71850-09-4PubChem CID 8970

Diisohexyl phthalate

Diisohexyl phthalate is a phthalate ester. Phthalate esters are esters of phthalic acid and are mainly used as plasticizers, primarily used to soften polyvinyl chloride. They are found in a number of products, including glues, building materials, personal care products, detergents and surfactants, packaging, children's toys, paints, pharmaceuticals, food products, and textiles. Phthalates are hazardous due to their ability to act as endocrine disruptors. They are being phased out of many products in the United States and European Union due to these health concerns. (L1903) — Toxin and Toxin Target Database (T3DB)

IUPAC name
bis(4-methylpentyl) benzene-1,2-dicarboxylate
Molecular formula
C20H30O4
Molecular weight
334.4 g/mol
Exact mass
334.21440943 Da
XLogP3
6.3
Topological polar surface area
52.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

146-50-91,2-Benzenedicarboxylic acid, diisohexyl ester1,2-Benzenedicarboxylic acid, bis(4-methylpentyl) ester1,2-Benzenedicarboxylic acid diisohexyl esterdiisohexyl benzene-1,2-dicarboxylateBis(4-methylpentyl) 1,2-benzenedicarboxylateEINECS 276-090-2Phthalic acid diisohexyl ester
16 more reported names
Phthalic acid di(4-methylpentyl) esterDiisohexyl phthalic acidRefChem:5878321,2-bis(4-methylpentyl) benzene-1,2-dicarboxylate276-090-2690-072-5Bis(4-methylpentyl) phthalateBis(4-methylpentyl)phthalatePhthalic acid, bis-4-methylpentyl esterPhthalic acid, diisohexyl ester1,2-Benzenedicarboxylic acid, bis(4-methylpentyl) ester (9CI); Bis(4-methylpentyl) phthalate;1,2-Benzenedicarboxylic acid, 1,2-bis(4-methylpentyl) esterdi-isohexyl phthalateBis(4-methylpentyl) phthalate #MSK1153Phthalic acid, di(4-methylpentyl) esterDB-318774
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Diisohexyl phthalate

Chemical / IUPAC name

Diisohexyl phthalate

Regulatory information

Regulation

(EU) 2021/850

See every entry this act set

Key data

CAS
71850-09-4
EC
276-090-2
Annex
II
Entry number
1652

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Diisohexyl phthalate

Diisohexyl phthalate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Diisohexyl phthalate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 71850-09-4 is the unique numerical identifier assigned to Diisohexyl phthalate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Diisohexyl phthalate

This page summarizes one Annex II record for Diisohexyl phthalate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Diisohexyl phthalate, but confirm any final regulatory decision against the current official annex wording and source files.

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