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Annex II Entry 1651 21/06/2021

Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate

Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1651

Chemical identity and properties

PubChem 2D chemical structure for CAS 400882-07-7
CAS 400882-07-7PubChem CID 11496052

Cyflumetofen

2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate is a nitrile that is acetonitrile in which the methyl hydrogens have been replaced by o-trifluoromethylbenzoyl, p-tert-butylphenyl, and (2-methoxyethoxy)carbonyl groups. It is a 2-methoxyethyl ester, a nitrile, a beta-ketoester and a member of (trifluoromethyl)benzenes. — ChEBI

IUPAC name
2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate
Molecular formula
C24H24F3NO4
Molecular weight
447.4 g/mol
Exact mass
447.16574273 Da
XLogP3
5.5
Topological polar surface area
76.4 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
8
Covalent units
1
Defined stereocentres
0

Also known as

QJW6N271192-methoxyethyl-(RS)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(alpha,alpha,alpha-trifluoro-o-tolyl)propionate2-methoxyethyl (RS)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(alpha,alpha,alpha-trifluoro-o-tolyl)propionateRefChem:581332CHEBI:81798BENZENEPROPANOIC ACID, ALPHA-CYANO-ALPHA-(4-(1,1-DIMETHYLETHYL)PHENYL)-BETA-OXO-2-(TRIFLUOROMETHYL)-, 2-METHOXYETHYL ESTERCyflumetofen [ISO]UNII-QJW6N27119
14 more reported names
2-Methoxyethyl 2-(4-(tert-butyl)phenyl)-2-cyano-3-oxo-3-(2-(trifluoromethyl)phenyl)propanoateC24H24F3NO4BENZENEPROPANOIC ACID, .ALPHA.-CYANO-.ALPHA.-(4-(1,1-DIMETHYLETHYL)PHENYL)-.BETA.-OXO-2-(TRIFLUOROMETHYL)-, 2-METHOXYETHYL ESTERBenzenepropanoic acid, .alpha.-cyano-.alpha.-[4-(1,1-dimethylethyl)phenyl]-.beta.-oxo-2-(trifluoromethyl)-, 2-methoxyethyl esterCYFLUMETOFEN [MI]CHEBI:136837EBC-12904HY-W663938AS-82676CS-0747570Cyflumetofen, PESTANAL(R), analytical standardEN300-19737091(RS)-2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(alpha,alpha,alpha-trifluoro-o-tolyl)propionate2-METHOXYETHYL (RS)-2-(4-TERT-BUTYLPHENYL)-2-CYANO-3-OXO-3-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-O-TOLYL)PROPIONATE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate

Chemical / IUPAC name

Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate

Regulatory information

Regulation

(EU) 2021/850

See every entry this act set

Key data

CAS
400882-07-7
EC
—
Annex
II
Entry number
1651

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1645
Nearby record in the same annex

Cobalt

CAS: 7440-48-4
EC: 231-158-0

What Annex II means for Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate

Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 400882-07-7 is the unique numerical identifier assigned to Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate

This page summarizes one Annex II record for Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cyflumetofen (ISO); 2-methoxyethyl (RS)-2- (4-tert-butylphenyl)-2-cyano-3-oxo- 3-(α,α,α-trifluoro-o-tolyl)propionate, but confirm any final regulatory decision against the current official annex wording and source files.

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