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Annex II Entry 1626 27/07/2020

Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5]

Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1626

Chemical identity and properties

PubChem 2D chemical structure for CAS 121158-58-5
CAS 121158-58-5PubChem CID 22833469

4-(3,4,5-Trimethylheptyl)phenol

IUPAC name
4-(3,4,5-trimethylheptyl)phenol
Molecular formula
C16H26O
Molecular weight
234.38 g/mol
Exact mass
234.198365449 Da
XLogP3
5.8
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:287462NOCAS_880593AOOKHLGAVNECET-UHFFFAOYSA-N
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match22833469

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5]

Chemical / IUPAC name

Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5]

Regulatory information

Regulation

(EU) 2019/1966

See every entry this act set

Key data

CAS
121158-58-5 [1]; 1801269-80-6 [2] ; 1801269-77-1 [3]; 210555-94-5 [4]; 74499-35-7 [5]
EC
310-154-3 [1]; - [2]; - [3]; 640-104-9 [4]; 616-100-8 [5]
Annex
II
Entry number
1626

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1622
Nearby record in the same annex

1-Vinylimidazole

CAS: 1072-63-5
EC: 214-012-0

What Annex II means for Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5]

Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 121158-58-5 [1]; 1801269-80-6 [2] ; 1801269-77-1 [3]; 210555-94-5 [4]; 74499-35-7 [5] is the unique numerical identifier assigned to Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5]

This page summarizes one Annex II record for Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Phenol, dodecyl-, branched [1]; Phenol, 2-dodecyl-, branched [2]; Phenol, 3-dodecyl-, branched [3]; Phenol, 4-dodecyl-, branched [4]; Phenol, (tetrapropenyl) derivatives [5], but confirm any final regulatory decision against the current official annex wording and source files.

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