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Annex II Entry 1384 27/07/2020

2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products

2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1384

Chemical identity and properties

PubChem 2D chemical structure for CAS 615-46-3
CAS 615-46-3PubChem CID 11997

2-Chloro-1,4-benzenediamine dihydrochloride

IUPAC name
2-chlorobenzene-1,4-diamine;dihydrochloride
Molecular formula
C6H9Cl3N2
Molecular weight
215.5 g/mol
Exact mass
213.983131 Da
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

2-Chloro-p-phenylenediamine dihydrochlorideHSDB 6246MJG61MCR0HNSC 6073EINECS 210-427-6p-Phenylenediamine, 2-chloro-, dihydrochloride1,4-Benzenediamine, 2-chloro-, dihydrochloride1,4-Benzenediamine, 2-chloro-, hydrochloride (1:2)
14 more reported names
NSC-6073RefChem:4682342Chloropphenylenediamine dihydrochloridepPhenylenediamine, 2chloro, dihydrochloride1,4Benzenediamine, 2chloro, dihydrochloride2-chlorobenzene-1,4-diamine dihydrochloride2-chlorobenzene-1,4-diamine, chloride, chlorideUNII-MJG61MCR0H2-Chlorobenzene-1,4-diammonium dichlorideGJCLKJLIKKFYAW-UHFFFAOYSA-N2-chlorobenzene-1,4-diaminedihydrochlorideDB-0539252-Chlorobenzene-1,4-diamine--hydrogen chloride (1/2)2-CHLOROBENZENE-1,4-DIAMMONIUM DICHLORIDE [HSDB]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 615-66-7
CAS 615-66-7PubChem CID 11998

2-Chloro-p-Phenylenediamine

2-chloro-1,4-phenylenediamine is a diamine that is 1,4-phenylenediamine substituted at position 2 by a chloro group. It has a role as a dye. It is a diamine and a member of monochlorobenzenes. It is functionally related to a 1,4-phenylenediamine. It is a conjugate base of a 2-chloro-1,4-phenylenediaminium. — ChEBI

IUPAC name
2-chlorobenzene-1,4-diamine
Molecular formula
C6H7ClN2
Molecular weight
142.58 g/mol
Exact mass
142.0297759 Da
XLogP3
1.6
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

2-Chloro-1,4-diaminobenzene1,4-Benzenediamine, 2-chloro-Ursol Brown O2-Chloro-1,4-phenylenediamine3-Chloro-4-aminoaniline1,4-Diamino-2-chlorobenzene2-Chloro-1,4-benzenediamineo-Chloro-p-phenylenediamine
16 more reported names
2-Chloro-4-phenylenediaminep-Phenylenediamine, 2-chloro-C.I. 760653-Chloro-p-fenylendiaminW949BCC82RCI 76065CHEBI:76598RefChem:470353210-441-22-Chlor-p-fenylendiamin3-Chlor-p-fenylendiaminHSDB 41262-Chlor-p-fenylendiamin [Czech]3-Chlor-p-fenylendiamin [Czech]2-Chloro-(1,4-phenylenediamine)3-Chloro-p-fenylendiamin [Czech]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 61702-44-1
CAS 61702-44-1PubChem CID 22584

2-Chloro-p-phenylenediamine sulfate

2-chloro-1,4-phenylenediamine sulfate is an arylammonium sulfate salt obtained by combining 2-chloro-1,4-phenylenediamine with one molar equivalent of sulfuric acid. It has a role as a dye. It contains a 2-chloro-1,4-phenylenediaminium. — ChEBI

IUPAC name
2-chlorobenzene-1,4-diamine;sulfuric acid
Molecular formula
C6H9ClN2O4S
Molecular weight
240.67 g/mol
Exact mass
239.9971556 Da
Topological polar surface area
135.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

2-chlorobenzene-1,4-diamine sulfate2-Chloro-1,4-phenylenediamine sulfate6219-71-2Fourrine SO1,4-Benzenediamine, 2-chloro-, sulfateFourrine 812-Cl-p-PDRenal SO
16 more reported names
2-CHLORO-1,4-BENZENEDIAMINE SULFATE2-Chlorobenzene-1,4-diammonium sulphateC.I. Oxidation Base 13Arenal brown soCCRIS 1452-Chloro p-phenylenediamine sulphatep-Phenylenediamine, 2-chloro-, sulfateC.I. 760663-Chloro-4-aminoaniline sulfateHSDB 6247NCI-C03316EINECS 228-291-1EINECS 262-915-32-Chloro-1,4-benzenediamine sulfate (1:1)COLOREX OCPPDSRODOL BROWN SO
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products

Chemical / IUPAC name

2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products

Regulatory information

Regulation

(EU) 2019/681

See every entry this act set

Key data

CAS
615-66-7; 61702-44-1 (sulfate); 615-46-3 (dihydrochloride)
EC
210-441-2; 262-915-3; 210-427-6
Annex
II
Entry number
1384

Inventory links for 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products

2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 615-66-7; 61702-44-1 (sulfate); 615-46-3 (dihydrochloride) is the unique numerical identifier assigned to 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products

This page summarizes one Annex II record for 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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