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Annex II Entry 1326 21/10/2010

3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products

3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1326

Chemical identity and properties

PubChem 2D chemical structure for CAS 102767-27-1
CAS 102767-27-1PubChem CID 21832405

HC Blue 10

IUPAC name
3-[4-[2-hydroxyethyl(methyl)amino]-2-nitroanilino]propane-1,2-diol
Molecular formula
C12H19N3O5
Molecular weight
285.30 g/mol
Exact mass
285.13247072 Da
XLogP3
0.4
Topological polar surface area
122.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:347085ICMWDHODFTWYFK-UHFFFAOYSA-N3-{4-[(2-Hydroxyethyl)(methyl)amino]-2-nitroanilino}propane-1,2-diol3-((4-((2-Hydroxyethyl)(methyl)amino)-2-nitrophenyl)amino)propane-1,2-diol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match21832405

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBINo exact record2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 173994-75-7
CAS 173994-75-7PubChem CID 21832404

1,a2-aPropanediol, 3-a[[4-a[(2-ahydroxyethyl)amethylamino]a-a2-anitrophenyl]aamino]a-a, hydrochloride (1:1)

IUPAC name
3-[4-[2-hydroxyethyl(methyl)amino]-2-nitroanilino]propane-1,2-diol;hydrochloride
Molecular formula
C12H20ClN3O5
Molecular weight
321.76 g/mol
Exact mass
321.1091484 Da
Topological polar surface area
122.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
7
Covalent units
2
Defined stereocentres
0

Also known as

3-{4-[(2-Hydroxyethyl)(methyl)amino]-2-nitroanilino}propane-1,2-diol--hydrogen chloride (1/1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
173994-75-7 / 102767-27-1
EC
—
Annex
II
Entry number
1326

Inventory links for 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products

Inventory Restriction reference
Ref 34187

HC BLUE NO. 10

CAS: 173994-75-7/102767-27-1

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products

3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 173994-75-7 / 102767-27-1 is the unique numerical identifier assigned to 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 3-[[4-[(2-Hydroxyethyl)methylamino]-2-nitrophenyl]amino]-1,2-propanediol and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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