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Annex II Entry 1278 21/10/2010

1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products

1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1278

Chemical identity and properties

PubChem 2D chemical structure for CAS 12217-43-5
CAS 12217-43-5PubChem CID 82972

Basic Blue 47

IUPAC name
1-amino-4-[4-[(dimethylamino)methyl]anilino]anthracene-9,10-dione
Molecular formula
C23H21N3O2
Molecular weight
371.4 g/mol
Exact mass
371.16337692 Da
XLogP3
4.7
Topological polar surface area
75.4 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

C.I. Basic Blue 47EINECS 235-398-7UNII-8G3UK6793U8G3UK6793UASTRAZON BLUE 3RLSUMIACRYL BLUE 3RLOWACRYL BLUE 47SUMIACRYL BLUE N 3RL
16 more reported names
AIZEN CATHILON BLUE 3RLHCALCOZINE ACRYLIC BLUE 3RLC.I. 611119,10-Anthracenedione, 1-amino-4-((4-((dimethylamino)methyl)phenyl)amino)-ANTHRAQUINONE, 1-AMINO-4-(.ALPHA.-DIMETHYLAMINO-P-TOLUIDINO)-RefChem:116613BASIC BLUE 47 [INCI]ANTHRAQUINONE, 1-AMINO-4-(ALPHA-DIMETHYLAMINO-P-TOLUIDINO)-235-398-71-Amino-4-((4-((dimethylamino)methyl)phenyl)amino)anthraquinone1-amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone1-Amino-4-{4-[(dimethylamino)methyl]anilino}anthracene-9,10-dioneIVFRHOQHKQWEHJ-UHFFFAOYSA-N1-amino-4-[4-(dimethylaminomethyl)anilino]anthracene-9,10-dione1-Amino-4-((4-((dimethylamino)methyl)phenyl)amino)anthracene-9,10-dione1-Amino-4-({4-[(dimethylamino)methyl]phenyl}amino)anthra-9,10-quinone
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match82972

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67905-56-0
CAS 67905-56-0PubChem CID 106055

9,10-Anthracenedione, 1-amino-4-((4-((dimethylamino)methyl)phenyl)amino)-, hydrochloride (1:1)

IUPAC name
1-amino-4-[4-[(dimethylamino)methyl]anilino]anthracene-9,10-dione;hydrochloride
Molecular formula
C23H22ClN3O2
Molecular weight
407.9 g/mol
Exact mass
407.1400546 Da
Topological polar surface area
75.4 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
5
Covalent units
2
Defined stereocentres
0

Also known as

EINECS 267-677-49,10-Anthracenedione, 1-amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]-, monohydrochloride1-Amino-4-(4-(alpha-(dimethylammonium)methyl)phenyl)aminoanthraquinone, chloride9,10-Anthracenedione, 1-amino-4-((4-((dimethylamino)methyl)phenyl)amino)-, monohydrochloride9,10-Anthracenedione, 1-amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]-, hydrochloride (1:1)RefChem:1074671-Amino-4-((4-((dimethylamino)methyl)phenyl)amino)anthraquinone monohydrochloride1-AMINO-4-[[4-[(DIMETHYLAMINO)METHYL]PHENYL]AMINO]ANTHRAQUINONE MONOHYDROCHLORIDE
2 more reported names
JPJZNMUFYKRLGZ-UHFFFAOYSA-N1-Amino-4-{4-[(dimethylamino)methyl]anilino}anthracene-9,10-dione--hydrogen chloride (1/1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
67905-56-0 / 12217-43-5
EC
267-677-4 / 235-398-7
Annex
II
Entry number
1278

Inventory links for 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products

Inventory Restriction reference
Ref 32065

BASIC BLUE 47

CAS: 67905-56-0
EC: 267-677-4

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products

1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 67905-56-0 / 12217-43-5 is the unique numerical identifier assigned to 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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