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Annex II Entry 1276 15/10/2010

Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products

Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1276

Chemical identity and properties

PubChem 2D chemical structure for CAS 7057-57-0
CAS 7057-57-0PubChem CID 81506

Meldola blue

IUPAC name
zinc;benzo[a]phenoxazin-9-ylidene(dimethyl)azanium;trichloride
Molecular formula
C18H15Cl3N2OZn
Molecular weight
447.1 g/mol
Exact mass
443.954138 Da
Topological polar surface area
24.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
5
Defined stereocentres
0

Also known as

RefChem:156316230-338-6EINECS 230-338-69-(Dimethylamino)benzo[a]phenoxazin-7-ium zinc chloride (1/1/3)9-(Dimethylamino)benzo(a)phenazin-7-ium chloride, compound with zinc chloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 966-62-1
CAS 966-62-1PubChem CID 101929

Basic Blue 6

IUPAC name
benzo[a]phenoxazin-9-ylidene(dimethyl)azanium chloride
Molecular formula
C18H15ClN2O
Molecular weight
310.8 g/mol
Exact mass
310.0872908 Da
Topological polar surface area
24.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
2
Defined stereocentres
0

Also known as

MeldolaNaphthol blueC.I. Basic Blue 6Naphthol blue (VAN)C.I. Basic Blue 6 (VAN)UNII-CP2ST8ED1OCP2ST8ED1OC.I. 51175
16 more reported names
NSC 9291NSC-9291EINECS 213-524-1CI 51175Benzo(a)phenazoxonium, 9-(dimethylamino)-, chlorideBenzo(a)phenoxazinium, 9-(dimethylamino)-, chlorideBenzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, chlorideBenzo(a)phenoxazin-7-ium, 9-(dimethylamino)-, chloride (1:1)9-DIMETHYLAMINOBENZO(A)PHENAZOXONIUM CHLORIDE9-(DIMETHYLAMINO)BENZO(A)PHENOXAZINIUM CHLORIDE9-(Dimethylamino)benzo(alpha)phenoxazin-7-ium chlorideBenzo(a)phenoxazin-7-ium, 9-(dimethylamino)-, chlorideBenzo(alpha)phenoxazin-7-ium,9-(dimethylamino)-, chlorideBenzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, chloride (1:1)RefChem:116614BASIC BLUE 6 [INCI]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
7057-57-0 / 966-62-1
EC
230-338-6 / 213-524-1
Annex
II
Entry number
1276

Inventory links for Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products

Inventory Restriction reference
Ref 32066

BASIC BLUE 6

CAS: 966-62-1
EC: 213-524-1

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products

Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 7057-57-0 / 966-62-1 is the unique numerical identifier assigned to Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products

This page summarizes one Annex II record for Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.

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