EU cosmetic ingredients, restrictions and safety

Annex II Entry 1106 CMR15/10/2010

(4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride

(4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1106

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 81880-96-8

CAS 81880-96-8PubChem CID 14234263

4-Hydrazino-N-methylbenzenemethanesulfonamide hydrochloride

IUPAC name: 1-(4-hydrazinylphenyl)-N-methylmethanesulfonamide;hydrochloride

Molecular formula: C8H14ClN3O2S
Molecular weight: 251.73 g/mol
Exact mass: 251.0495256 Da
Topological polar surface area: 92.6 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 5
Covalent units: 2
Defined stereocentres: 0

Also known as

E6PT6JNT3AN-Methyl-4-diazanylsulfabenzamide hydrochloride4-Hydrazino-N-methylbenzene methanesulphonamide hydrochlorideBenzenemethanesulfonamide, 4-hydrazinyl-N-methyl-, hydrochloride (1:1)EC 406-090-1(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochlorideRefChem:523623406-090-1

16 more reported names

1-(4-HYDRAZINYLPHENYL)-N-METHYLMETHANESULFONAMIDE HYDROCHLORIDESumatriptan Hydrazine Impurity4-Hydrazino-N-methyl Benzene Methanesulfonamide Hydrochloride Salt1-(4-Hydrazineylphenyl)-N-methylmethanesulfonamide hydrochlorideWZZPGBAXFSIKJJ-UHFFFAOYSA-N4-HYDRAZINO-N-METHYLBENZENEMETHANESULFONAMIDE MONOHYDROCHLORIDEUNII-E6PT6JNT3ADS-83474-Hyrazinophenyl-N-methyl-methanesulfonamideCS-0150986N-Methyl-4-diazanyltoluenesulfamine hydrochloride,4-hydrazino-N-methyl-benzylsulfonamide hydrochloride4-hydrazino-N-methylbenzenemethanesulphonamide hydrochloride1-(4-hydrazinophenyl)-N-methyl-methanesulfonamide;hydrochloride1-(4-Hydrazinophenyl)-N-methylmethanesulfonamide Hydrochloride4-hydrazino-n-methyl benzene methanesulfonamide hydrochloride

Open full PubChem record PubChem annotations 3D structure image

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

(4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride

Regulatory information

Regulation

See every entry this act set

SCCS opinions

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 2	—	✓	—

Key data

CAS

EC

Annex

Entry number

1106

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

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Annex II 1101

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Annex II 1111

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Annex II 1100

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EC: 232-104-9

Annex II 1112

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Diethylcarbamoyl-chloride

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Annex II 1099

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What Annex II means for (4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride

(4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

Verify this substance is absent from all raw materials and finished formulations.
Request absence confirmation or CoA from raw material suppliers.
Document the screening result in the Product Information File (PIF).
This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. (4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 81880-96-8 is the unique numerical identifier assigned to (4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

(4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

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Source note for Annex II record (4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride

This page summarizes one Annex II record for (4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for (4-Hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride, but confirm any final regulatory decision against the current official annex wording and source files.

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