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Annex II Entry 1100 CMR29/10/2010

Nickel sulphate

Nickel sulphate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1100
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 7786-81-4
CAS 7786-81-4PubChem CID 24586

Nickel Sulfate

Nickel sulfate is a metal sulfate having nickel(2+) as the metal ion. It has a role as an allergen. It contains a nickel(2+). — ChEBI

IUPAC name
nickel(2+) sulfate
Molecular formula
NiO4S
Molecular weight
154.76 g/mol
Exact mass
153.887071 Da
Topological polar surface area
88.6 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
0

Also known as

Nickel sulphateNickelous sulfateNickel(II) sulfateNickel sulfate(1:1)Nickel(II) sulfate (1:1)Sulfuric acid, nickel(2+)saltNickel(2+) sulfate (1:1)Sulphuric acid, nickel(II) salt
16 more reported names
NiSO4Nickel(2+)sulfate(1:1)Sulfuric acid nickel(2+) salt4FLT4T3WUNNCI-C60344Nickel (II) sulfate hexahydrateSulfuric acid, nickel(2+) salt (1:1)CHEBI:53001NICKELOUS SULPHATENSC-51152Blue saltRefChem:6060nickel(2+) ion sulfate232-104-9Nickel sulfate (1:1)Nickel sulfate (VAN)
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Nickel sulphate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1A✓——
Cat. 1B——✓
Cat. 2—✓—

Key data

CAS
7786-81-4
EC
232-104-9
Annex
II
Entry number
1100

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1098
Nearby record in the same annex

Heptachlor

CAS: 76-44-8
EC: 200-962-3
Annex II 1105
Nearby record in the same annex

Toxaphene

CAS: 8001-35-2
EC: 232-283-3

What Annex II means for Nickel sulphate

Nickel sulphate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Nickel sulphate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 7786-81-4 is the unique numerical identifier assigned to Nickel sulphate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Nickel sulphate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Nickel sulphate

This page summarizes one Annex II record for Nickel sulphate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Nickel sulphate, but confirm any final regulatory decision against the current official annex wording and source files.

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