Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 1069 CMR21/10/2010

Toluidinium chloride

Toluidinium chloride is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1069
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 540-23-8
CAS 540-23-8PubChem CID 10891

Benzenamine, 4-methyl-, hydrochloride (1:1)

P-toluidine hydrochloride appears as off-white to grayish-white crystals. (NTP, 1992) — CAMEO Chemicals

IUPAC name
4-methylaniline;hydrochloride
Molecular formula
C7H10ClN
Molecular weight
143.61 g/mol
Exact mass
143.0501770 Da
Topological polar surface area
26.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
1
Covalent units
2
Defined stereocentres
0

Also known as

p-Toluidine hydrochloride4-Aminotoluene hydrochloride4-Methylanilinium chloridep-Methylanilinium chloride4-Methylbenzenamine hydrochloridep-Toluidine, hydrochloridePT5II901IFP-METHYLANILINE HYDROCHLORIDE
16 more reported names
4-METHYLPHENYLAMMONIUM CHLORIDE4-toluidine hydrochlorideRefChem:169393208-740-84-Methylaniline hydrochloridep-Toluidine.HClBenzenamine, 4-methyl-, hydrochloridep-TOLUIDINE HClP-TOLUIDINIUM CHLORIDEpara-toluidine hydrochlorideTox21_200517CAS-540-23-8LS-132864-Methylaniline--hydrogen chloride (1/1)DB-052460T0303
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Toluidinium chloride

Chemical / IUPAC name

Benzenamine, 4-methyl-, hydrochloride (1:1)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
540-23-8
EC
208-740-8
Annex
II
Entry number
1069

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1068
Nearby record in the same annex

DNOC (ISO)

CAS: 534-52-1
EC: 208-601-1
Annex II 1072
Nearby record in the same annex

Fenthion (ISO)

CAS: 55-38-9
EC: 200-231-9
Annex II 1073
Nearby record in the same annex

Chlordane, pur

CAS: 57-74-9
EC: 200-349-0
Annex II 1062
Nearby record in the same annex

Iprodione

CAS: 36734-19-7
EC: 253-178-9
Annex II 1075
Nearby record in the same annex

Fenarimol (ISO)

CAS: 60168-88-9
EC: 262-095-7

What Annex II means for Toluidinium chloride

Toluidinium chloride is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Toluidinium chloride is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 540-23-8 is the unique numerical identifier assigned to Toluidinium chloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Toluidinium chloride has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record Toluidinium chloride

This page summarizes one Annex II record for Toluidinium chloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Toluidinium chloride, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Toluidinium chloride and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Toluidinium chloride side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II