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Annex II Entry 1058 CMR17/12/2010

Diuron (ISO)

Diuron (ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1058
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 330-54-1
CAS 330-54-1PubChem CID 3120

Diuron

Diuron is a member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group. It has a role as a urea herbicide, a mitochondrial respiratory-chain inhibitor, a photosystem-II inhibitor, a xenobiotic and an environmental contaminant. It is a 3-(3,4-substituted-phenyl)-1,1-dimethylurea and a dichlorobenzene. — ChEBI

IUPAC name
3-(3,4-dichlorophenyl)-1,1-dimethylurea
Molecular formula
C9H10Cl2N2O
Molecular weight
233.09 g/mol
Exact mass
232.0170183 Da
XLogP3
2.7
Topological polar surface area
32.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

DCMUDuranDichlorfenidimKarmexDynexVonduronDailonMarmer
16 more reported names
Karmex DWDi-onUrox DCekiuronCrisuronLucenitUnidron1,1-Dimethyl-3-(3,4-dichlorophenyl)urea1-(3,4-Dichlorophenyl)-3,3-dimethylureaN'-(3,4-Dichlorophenyl)-N,N-dimethylureaDiuron NortoxKarmex DPreventol A 6Karmex Diuron HerbicideDiuron 4LDirex 4L
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Diuron (ISO)

Chemical / IUPAC name

3-(3,4-dichlorophenyl)-1,1-dimethylurea

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
330-54-1
EC
206-354-4
Annex
II
Entry number
1058

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1057
Nearby record in the same annex

Aldrin (ISO)

CAS: 309-00-2
EC: 206-215-8
Annex II 1059
Nearby record in the same annex

Linuron (ISO)

CAS: 330-55-2
EC: 206-356-5
Annex II 1056
Nearby record in the same annex

1,2,4-Triazole

CAS: 288-88-0
EC: 206-022-9
Annex II 1062
Nearby record in the same annex

Iprodione

CAS: 36734-19-7
EC: 253-178-9
Annex II 1052
Nearby record in the same annex

Chinomethionate

CAS: 2439-01-2
EC: 219-455-3

What Annex II means for Diuron (ISO)

Diuron (ISO) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Diuron (ISO) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 330-54-1 is the unique numerical identifier assigned to Diuron (ISO) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Diuron (ISO) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Diuron (ISO)

This page summarizes one Annex II record for Diuron (ISO) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Diuron (ISO), but confirm any final regulatory decision against the current official annex wording and source files.

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