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Annex II Entry 1054 CMR21/10/2010

5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO)

5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1054
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 2593-15-9
CAS 2593-15-9PubChem CID 17432

Etridiazole

Etridiazole is a member of the class of thiadiazoles that is 1,2,4-thiadiazole which is substituted at positions 3 and 5 by trichloromethyl and ethoxy groups, respectively. A fungicide, it has been used particularly for the control of Phytophthora and Pythium species in soils. It has a role as a nitrification inhibitor and an antifungal agrochemical. It is an aromatic ether, an organochlorine compound, a member of thiadiazoles and a thiadiazole antifungal agent. — ChEBI

IUPAC name
5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole
Molecular formula
C5H5Cl3N2OS
Molecular weight
247.5 g/mol
Exact mass
245.918817 Da
XLogP3
2.5
Topological polar surface area
63.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

EchlomezoleEthazolEchlomezolKobanEtridiazolAaterraPansoilPlanvate
16 more reported names
TrubanTerracoatTERRAZOLEEtcmtbDwellETMTTerracoat L21Terrachlor-super XTerrafloOlin mathieson 2,424ETHAZOLEEthazole (fungicide)5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole1,2,4-Thiadiazole, 5-ethoxy-3-(trichloromethyl)-3-(Trichloromethyl)-5-ethoxy-1,2,4-thiadiazoleSanyard
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO)

Chemical / IUPAC name

Etridiazole (ISO)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
2593-15-9
EC
219-991-8
Annex
II
Entry number
1054

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1052
Nearby record in the same annex

Chinomethionate

CAS: 2439-01-2
EC: 219-455-3
Annex II 1056
Nearby record in the same annex

1,2,4-Triazole

CAS: 288-88-0
EC: 206-022-9
Annex II 1057
Nearby record in the same annex

Aldrin (ISO)

CAS: 309-00-2
EC: 206-215-8
Annex II 1058
Nearby record in the same annex

Diuron (ISO)

CAS: 330-54-1
EC: 206-354-4
Annex II 1049
Nearby record in the same annex

Propyzamide

CAS: 23950-58-5
EC: 245-951-4
Annex II 1059
Nearby record in the same annex

Linuron (ISO)

CAS: 330-55-2
EC: 206-356-5

What Annex II means for 5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO)

5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 2593-15-9 is the unique numerical identifier assigned to 5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO)

This page summarizes one Annex II record for 5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 5-Ethoxy-3-trichloromethyl-1,2,4-thiadiazole (Etridiazole - ISO), but confirm any final regulatory decision against the current official annex wording and source files.

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