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Annex II Entry 1031 CMR24/11/2016

Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2]

Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1031
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 1689-84-5
CAS 1689-84-5PubChem CID 15531

Bromoxynil

3,5-dibromo-4-hydroxybenzonitrile is a dibromobenzene that is 2,6-dibromophenol substituted by a cyano group at position 4. It has a role as a herbicide, a xenobiotic and an environmental contaminant. It is a hydroxynitrile, a member of phenols and a dibromobenzene. It is functionally related to a 2,6-dibromophenol. It is a conjugate acid of a 3,5-dibromo-4-oxidobenzonitrile(1-). — ChEBI

IUPAC name
3,5-dibromo-4-hydroxybenzonitrile
Molecular formula
C7H3Br2NO
Molecular weight
276.91 g/mol
Exact mass
276.85609 Da
XLogP3
3.5
Topological polar surface area
44.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

BrominalBrominilBroxynilSabreBrominexLabuctrilPardnerToplan
16 more reported names
2,6-Dibromo-4-cyanophenolBrittoxBuctrilLabuctril 25Chipco buctrilME 4 BrominalNu-lawn weederOxytril MBromotrilCertrol BLitarol MBuctril industrialChipco crab-kleen4-Cyano-2,6-dibromophenolButilchorofosNovacorn
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 56634-95-8
CAS 56634-95-8PubChem CID 62119

Bromoxynil heptanoate

IUPAC name
(2,6-dibromo-4-cyanophenyl) heptanoate
Molecular formula
C14H15Br2NO2
Molecular weight
389.08 g/mol
Exact mass
388.94490 Da
XLogP3
5.2
Topological polar surface area
50.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2,6-Dibromo-4-cyanophenyl heptanoateBuctril 4Bromoxynil heptanoate [ISO]UNII-EK18N93FQBEK18N93FQBEINECS 260-300-4Heptanoic acid, 2,6-dibromo-4-cyanophenyl esterEPA Pesticide Chemical Code 128920
4 more reported names
RefChem:121658BROMOXYNIL-HEPTANOATEBHZWBQPHPLFZSV-UHFFFAOYSA-NBromoxynil-heptanoate 100 microg/mL in Acetonitrile
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2]

Chemical / IUPAC name

Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓
when C=>5%

Key data

CAS
1689-84-5 [1] / 56634-95-8 [2]
EC
216-882-7 [1] / 260-300-4 [2]
Annex
II
Entry number
1031

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

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EC: 240-110-8
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Benomyl (ISO)

CAS: 17804-35-2
EC: 241-775-7
Annex II 1027
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Daminozide

CAS: 1596-84-5
EC: 216-485-9
Annex II 1036
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Chlorothalonil

CAS: 1897-45-6
EC: 217-588-1
Annex II 1025
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Monuron

CAS: 150-68-5
EC: 205-766-1

What Annex II means for Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2]

Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 1689-84-5 [1] / 56634-95-8 [2] is the unique numerical identifier assigned to Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2]

This page summarizes one Annex II record for Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Bromoxynil (ISO) 3,5-Dibromo-4-hydroxybenzonitrile [1] and Bromoxynil heptanoate (ISO) [2], but confirm any final regulatory decision against the current official annex wording and source files.

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