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Annex II Entry 1030 CMR24/11/2016

4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2]

4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1030
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 1689-83-4
CAS 1689-83-4PubChem CID 15530

Ioxynil

Ioxynil is a nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5. It has a role as a herbicide, a xenobiotic and an environmental contaminant. It is a nitrile and an iodophenol. — ChEBI

IUPAC name
4-hydroxy-3,5-diiodobenzonitrile
Molecular formula
C7H3I2NO
Molecular weight
370.91 g/mol
Exact mass
370.83041 Da
XLogP3
2.0
Topological polar surface area
44.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

ActrilBentrol3,5-Diiodo-4-hydroxybenzonitrileTrevespanCertrolActrilawnCipotrilJoxynil
16 more reported names
LoxynilIotoxBenzonitrile, 4-hydroxy-3,5-diiodo-2,6-Diiodo-4-cyanophenolBANTROL4-Cyano-2,6-diiodophenol4-Cyano-2,6-dijodphenolM&B 8873ACP 63303Benzonitrile, 3,5-diiodo-4-hydroxy-3,5-Dijod-4-hydroxy-benzonitrilCA 69-154-Hydroxy-3,5-di-iodophenyl cyanide8Y734M4V9ECHEBI:81821RefChem:148615
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3861-47-0
CAS 3861-47-0PubChem CID 19730

Ioxynil octanoate

Ioxynil octanoate is a member of phenols and a benzoate ester. — ChEBI

IUPAC name
(4-cyano-2,6-diiodophenyl) octanoate
Molecular formula
C15H17I2NO2
Molecular weight
497.11 g/mol
Exact mass
496.93487 Da
XLogP3
5.7
Topological polar surface area
50.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

4-Cyano-2,6-diiodophenyl octanoate3,5-Diiodo-4-octanoyloxybenzonitrile3,5-Diiodo-4-hydroxybenzonitrile octanoateIoxynil octanoate [BSI:ISO]RIP-15830OxytrilOctanoic acid, 4-cyano-2,6-diiodophenyl esterBenzonitrile, 3,5-diiodo-4-hydroxy-, octanoate
16 more reported names
Benzonitrile, 3,5-diiodo-4-octanoyloxy-M&B 11,461EINECS 223-375-475K1F1JBKRBRN 2756640STELLOX4-Cyano-2,6-dijodphenol caprysaeureesterBENTROL LOctanoic acid, ester with 4-hydroxy-3,5-diiodobenzonitrile3,5-Dijod-4-hydroxy-benzonitril caprysaeureester4-Cyano-2,6-dijodphenol caprysaeureester [German]MB-11641IOXYNIL OCTANOATE [MI]3,5-Dijod-4-hydroxy-benzonitril caprysaeureester [German]IOXYNIL OCTANOATE [ISO]Octanoic acid, (4-cyano-2,6-diiodo)phenyl ester
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2]

Chemical / IUPAC name

4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓
when C=>5%

Key data

CAS
1689-83-4 [1] / 3861-47-0 [2]
EC
216-881-1 [1] / 223-375-4[2]
Annex
II
Entry number
1030

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1028
Nearby record in the same annex

Alachlor (ISO)

CAS: 15972-60-8
EC: 240-110-8
Annex II 1027
Nearby record in the same annex

Daminozide

CAS: 1596-84-5
EC: 216-485-9
Annex II 1035
Nearby record in the same annex

Benomyl (ISO)

CAS: 17804-35-2
EC: 241-775-7
Annex II 1025
Nearby record in the same annex

Monuron

CAS: 150-68-5
EC: 205-766-1
Annex II 1036
Nearby record in the same annex

Chlorothalonil

CAS: 1897-45-6
EC: 217-588-1

What Annex II means for 4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2]

4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 1689-83-4 [1] / 3861-47-0 [2] is the unique numerical identifier assigned to 4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2]

This page summarizes one Annex II record for 4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-hydroxy-3,5-diiodobenzonitrile [1]; 4-Cyano-2,6-diiodophenyl octanoate [2], but confirm any final regulatory decision against the current official annex wording and source files.

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