Is CUCURBITURILS safe to use in EU cosmetics?

CUCURBITURILS is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does CUCURBITURILS serve in cosmetics?

According to the EU CosIng inventory, CUCURBITURILS carries the following function designation(s): ABSORBENT, CHELATING, EMULSION STABILISING, FILM FORMING.

How do I check if my formula contains CUCURBITURILS?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-916232023-07-24

CUCURBITURILS

Cucurbiturils are cyclic molecules that consist of glycouril units linked by methylene bridges, where n can be 5, 6, 7 or 8.

CUCURBITURILS is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 259886-49-2

CAS 259886-49-2PubChem CID 6096206

Cucurbit[5]uril

Cucurbit[5]uril is a cucurbituril. — ChEBI

Molecular formula: C30H30N20O10
Molecular weight: 830.7 g/mol
Exact mass: 830.24537723 Da
XLogP3: -5.7
Topological polar surface area: 236.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 10
Covalent units: 1
Defined stereocentres: 0

Also known as

cucurbit(5)urilCB[5]Cucurbit[n]uril aCHEBI:51435VKSVEHYLRGITRK-UHFFFAOYSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:51435
PubMed:22624150
PubMed:22471316
PubMed:22129203
PubMed:21761833
PubMed:21404420
PubMed:20379551
PubMed:19191519
PubMed:19175303
PubMed:18463754
PubMed:17960900
PubMed:17909488
PubMed:15148439

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 259886-50-5

CAS 259886-50-5PubChem CID 6096207

Cucurbit[7]uril (CB[7]) hydrate

Cucurbit[7]uril is a cucurbituril. — ChEBI

IUPAC name: 3,5,8,10,13,15,18,20,23,25,28,30,33,35,36,38,40,42,46,48,50,52,54,56,58,60,62,64-octacosazadocosacyclo[30.3.3.36,7.311,12.316,17.321,22.326,27.22,36.231,38.13,35.15,8.110,13.115,18.120,23.125,28.130,33.140,46.142,64.148,50.152,54.156,58.160,62]heptacontane-39,41,43,44,45,47,49,51,53,55,57,59,61,63-tetradecone

Molecular formula: C42H42N28O14
Molecular weight: 1163.0 g/mol
Exact mass: 1162.34352813 Da
XLogP3: -8.0
Topological polar surface area: 330.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 14
Covalent units: 1
Defined stereocentres: 0

Also known as

Cucurbit(7)uril (CB(7)) hydrateRefChem:579526811-749-5cucurbit[7]urilCucurbit[7]uril hydrateCB[7]QQ7SAMPL3, H2

7 more reported names

CHEBI:51434ZDOBFUIMGBWEAB-UHFFFAOYSA-NC42H42N28O14BS-51452HY-104086CS-0030779T9068

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:51434
ChEMBL:CHEMBL3770339
EPA DTXSID:DTXSID301316938
PubMed:23009313
PubMed:22969015
PubMed:22959366
PubMed:22946446
PubMed:22860771
PubMed:22852591
PubMed:22710743
PubMed:22690827
PubMed:22683553
PubMed:22646470
PubMed:22635275
PubMed:22618533

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 259886-51-6

CAS 259886-51-6PubChem CID 16133299

Cucurbit[8]uril

Cucurbit[8]uril is a cucurbituril. — ChEBI

IUPAC name: 3,5,8,10,13,15,18,20,23,25,28,30,33,35,38,40,41,43,45,47,51,53,55,57,59,61,63,65,67,69,71,73-dotriacontazapentacosacyclo[35.3.3.36,7.311,12.316,17.321,22.326,27.331,32.22,41.236,43.13,40.15,8.110,13.115,18.120,23.125,28.130,33.135,38.145,51.147,73.153,55.157,59.161,63.165,67.169,71]octacontane-44,46,48,49,50,52,54,56,58,60,62,64,66,68,70,72-hexadecone

Molecular formula: C48H48N32O16
Molecular weight: 1329.1 g/mol
Exact mass: 1328.39260358 Da
XLogP3: -9.1
Topological polar surface area: 377.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 16
Covalent units: 1
Defined stereocentres: 0

Also known as

CUCURBIT(8)URILCB[8]Cucurbit[8]uril hydrateCucurbit[8]uril (CB[8]) hydrate, 99+%C48H48N32O16Cucurbit[8]uril (CB[8]) hydrateCurcubit[8]urilCucurbit[8]uril hydrate contains acid of crystalization

8 more reported names

SAMPL3, H3Cucurbit[8]uril (CB[8])CHEBI:51433BS-14119DA-52159HY-103689CS-0031079C8L

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:51433
PubMed:23042328
PubMed:23008831
PubMed:22907929
PubMed:22842400
PubMed:22832698
PubMed:22758793
PubMed:22735549
PubMed:22730071
PubMed:22587703
PubMed:22388790
PubMed:22366954
PubMed:22336996

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 80262-44-8

CAS 80262-44-8PubChem CID 196163

Cucurbituril

Cucurbit[6]uril is a cucurbituril. — ChEBI

IUPAC name: 3,5,8,10,13,15,18,20,23,25,28,30,31,33,35,37,41,43,45,47,49,51,53,55-tetracosazanonadecacyclo[25.3.3.36,7.311,12.316,17.321,22.22,31.226,33.13,30.15,8.110,13.115,18.120,23.125,28.135,41.137,55.143,45.147,49.151,53]hexacontane-34,36,38,39,40,42,44,46,48,50,52,54-dodecone

Molecular formula: C36H36N24O12
Molecular weight: 996.8 g/mol
Exact mass: 996.29445268 Da
XLogP3: -6.8
Topological polar surface area: 283.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 12
Covalent units: 1
Defined stereocentres: 0

Also known as

cucurbit(n)urilcucurbit(n)urilsRefChem:128733CHEBI:51431cucurbit[6]urilCucurbit[6]uril hydrateCucurbit(6)urilCucurbit[n]uril b

11 more reported names

CB[6]CHEBI:51432Cucurbit[6]uril (CB[6]) hydrate, 99%Cucurbit[6]uril hydrate, contains acid of crystalizationCucurbituril [6]C36H36N24O12TSH-00019HY-W130354BS-17595CS-01884403,5,8,10,13,15,18,20,23,25,28,30,31,33,35,37,41,43,45,47,49,51,53,55-tetracosazanonadecacyclo[25.3.3.36,7.311,12.316,17.321,22.2

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:51432
EPA DTXSID:DTXSID101317823
PubMed:22961988
PubMed:22946446
PubMed:22864828
PubMed:22854225
PubMed:22743794
PubMed:22717946
PubMed:22650758
PubMed:22595678
PubMed:22545413
PubMed:22540671
PubMed:22512431
PubMed:22471316

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 91623
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2023-07-24

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for CUCURBITURILS

INCI name

CUCURBITURILS

Description

Cucurbiturils are cyclic molecules that consist of glycouril units linked by methylene bridges, where n can be 5, 6, 7 or 8.

Record provenance

Inventory reference: cosing-live-91623
Imported identity: CUCURBITURILS
Source update: 2023-07-24

European Commission CosIng source notes

Annex records for CUCURBITURILS

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Key data

CAS

80262-44-8/ 259886-51-6/ 259886-50-5/ 259886-49-2

-/ - /- /-

Restriction

—

Function

ABSORBENT: Taking up water- and/or oil-soluble (dissolved or finely dispersed) substances.
CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
EMULSION STABILISING: Helping the process of emulsification and improving emulsion stability and shelf-life.
FILM FORMING: Producing (upon application) a continuous film on the skin, hair or nails.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7706 · CUCURBITURILS

Ingredients with overlapping formulation functions

COCONUT OIL ETHYL FERULATE ESTERSABSORBENT, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

COLLOIDAL OATMEALABRASIVE, ABSORBENT, BULKING, SKIN PROTECTING

CORN STARCH MODIFIEDABSORBENT, FILM FORMING, SKIN CONDITIONING, VISCOSITY CONTROLLING

COTTONABSORBENT; ANTICAKING; BULKING; OPACIFYING; SLIP MODIFIER; SKIN CONDITIONING - MISCELLANEOUS

CURCUBITURILSABSORBENT, CHELATING, EMULSION STABILISING, FILM FORMING

CYCLODEXTRINABSORBENT, CHELATING

DEXTRINABSORBENT, BINDING, BULKING, VISCOSITY CONTROLLING

DIETHYLAMINOETHYL CELLULOSEABSORBENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CUCURBITURILS appears in the CosIng inventory

The CosIng inventory lists CUCURBITURILS as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CUCURBITURILS is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CUCURBITURILS is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CUCURBITURILS carries the following function designation(s):

CAS 80262-44-8/ 259886-51-6/ 259886-50-5/ 259886-49-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for CUCURBITURILS

This page reproduces the CosIng inventory entry for CUCURBITURILS from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CUCURBITURILS and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Regulatory evidence by market

Chemical identity and properties

Cucurbit[5]uril

Cucurbit[7]uril (CB[7]) hydrate

Cucurbit[8]uril

Cucurbituril

Official European Commission record

Inventory details for CUCURBITURILS

INCI name

Description

Record provenance

Annex records for CUCURBITURILS

Browse EU annexes

Search annex entries

Key data

Official EU ingredient-name evidence

Related inventory evidence

Ingredients with overlapping formulation functions

Additional official and scientific sources

How CUCURBITURILS appears in the CosIng inventory

Frequently asked questions

Is CUCURBITURILS safe to use in EU cosmetics?

What function does CUCURBITURILS serve in cosmetics?

What other records share CAS number 80262-44-8/ 259886-51-6/ 259886-50-5/ 259886-49-2?

How do I check if my formula contains CUCURBITURILS?

Source note for CUCURBITURILS

Tools & next steps

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